AI Article Synopsis
- Corynebacterium auriscanis is commonly found in dogs with skin infections and can spread to humans through bites, but its pathogenic functions are not well understood.
- This study aimed to analyze the genomes of three C. auriscanis strains to identify genes linked to its virulence and survival mechanisms.
- Findings revealed 42 potential virulence factors, but none categorized as true virulence factors, indicating that C. auriscanis behaves more like an opportunistic pathogen rather than a primary one.
Article Abstract
Background: Corynebacterium auriscanis is a bacterial species frequently isolated from dogs with external otitis or dermatitis and a zoonotic pathogen transmitted by dog bite. It is considered an opportunistic pathogen, but its pathogenicity mechanisms are poorly studied. Comparative genomics can identify virulence and niche factors that could contribute to understanding its lifestyle.
Objectives: The objectives of this project was to compare genomes of C. auriscanis to identify genes related to its virulence and lifestyle.
Methods: The genome of strain 32 was sequenced using Illumina HiSeq 2500 (Illumina, CA, USA) and assembled using Unicycler. The two other non-redundant genomes from the same species available in GenBank were included in the analysis. All genomes were annotated and checked for taxonomy, assembly quality, mobile elements, CRISPR-Cas systems, and virulence and antimicrobial resistance genes. The virulence genes in the three genomes were compared to the ones from other pathogens commonly isolated with C. auriscanis.
Findings: The species has 42 virulence factors that can be classified as niche factors, due to the absence of true virulence factors found in primary pathogens. The gene rbpA could confer basal levels of resistance to rifampin.
Main Conclusions: The absence of true virulence factors in the three genomes suggests C. auriscanis has an opportunistic pathogen lifestyle.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508509 | PMC |
| http://dx.doi.org/10.1590/0074-02760240156 | DOI Listing |
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