A translational approach for understanding hyperalgesia: What has the high-frequency electrical stimulation model taught us?

J Neurophysiol

Health Psychology, Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium.

Published: December 2024

AI Article Synopsis

  • * Research indicates that HFS not only affects the spinal cord but also heightens cortical responses to painful stimuli in animal models.
  • * The study raises questions about whether these heightened cortical responses are linked to spinal LTP and if similar effects occur in humans.

Article Abstract

This Mini-Review is based on the following article: Meijs S, Andreis FR, Janjua TAM, Graven-Nielsen T, Jensen W. High-frequency electrical stimulation increases cortical excitability and mechanical sensitivity in a chronic large animal model. . August 13, 2024. doi: 10.1097/j.pain.0000000000003354. High-frequency electrical stimulation (HFS) of C-fiber nociceptors induces long-term potentiation (LTP) at the first spinal synapse. This spinal LTP is believed to play a role in the amplification of pain. However, the effects of HFS are probably not restricted to the spinal cord. This study by Meijs et al. (2024) showed that HFS increases cortical responses to noxious stimuli in a porcine model. Are these increased cortical responses a correlate of spinal LTP and do we observe the same in humans?

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Source
http://dx.doi.org/10.1152/jn.00407.2024DOI Listing

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