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Revisiting immunity vs. exposure in schistosomiasis: A mathematical modeling study of delayed concomitant immunity. | LitMetric

AI Article Synopsis

  • - The study investigates the roles of exposure to schistosomiasis and acquired immunity in infection epidemiology, emphasizing that both factors significantly influence infection patterns in humans.
  • - Researchers developed a new transmission model that includes the effects of acquired immunity, particularly from dying worms, along with variations in exposure based on age and sex, using data from a community in Uganda.
  • - Findings indicate that both model variations, with or without delayed immunity, effectively explain infection trends, but acquired immunity plays a crucial role in shaping long-term responses to mass drug administration efforts for schistosomiasis elimination.

Article Abstract

The relative contributions of exposure vs. acquired immunity to the epidemiology of human schistosomiasis has been long debated. While there is considerable evidence that humans acquire partial immunity to infection, age- and sex-related contact patterns with water bodies contaminated with infectious cercarial schistosome larvae also contribute to typical epidemiological profiles of infection. Here, we develop a novel schistosome transmission model that incorporates both partially protective "delayed concomitant" acquired immunity-stimulated by dying worms-and host age- and sex-dependent patterns of exposure. We use a contemporary Bayesian approach to fit the model to historical individual data on exposure to infectious cercaria, eggs per gram of feces, and immunoglobulin E antibodies specific to Tegumental-Allergen-Like protein 1 collected from a highly endemic community in Uganda, estimating the relative contributions of exposure and acquired immunity. We find that model variants incorporating or omitting delayed concomitant immunity describe equally well the age- and sex-specific immunoepidemiological patterns observed before intervention and 18 months after treatment. Over longer time horizons, we find that acquired immunity creates subtle differences in immunoepidemiological profiles during routine mass drug administration that may confer resilience against elimination. We discuss our findings in the broader context of the immunoepidemiology of schistosomiasis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521328PMC
http://dx.doi.org/10.1093/pnasnexus/pgae471DOI Listing

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