AI Article Synopsis
- Long-term tolerance without immunosuppressive drugs is a key aim in transplantation, which has yet to be achieved.
- New research highlights the role of gut microbiota in immune regulation, suggesting it could lead to innovative treatments.
- Tryptophan (Trp) and its metabolites are being explored for their effects on immune responses and their potential to enhance transplant survival.
Article Abstract
Long-term tolerance in the absence of immunosuppressive drugs is a major goal in the transplantation field, not yet attained. Recent research on the role of commensal microbiota in the control of immunity has opened new avenues for the search of novel clinical interventions. Indeed, products of intestinal metabolism generated by both host cells and the microbiota have been identified as modulators of the immune response. Among these, tryptophan (Trp) and its derivatives are being investigated to understand their impact on alloimmunity and their potential usefulness as therapeutic targets to improve allograft survival. Here, we reviewed the latest findings on the contribution of Trp metabolic pathways to transplant outcomes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518742 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1395421 | DOI Listing |
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