Photochemical reaction is expected to become a promising type of green chemistry with merits of operational flexibility, excellent regioselectivity, high yield, and mild reaction condition. Recently, aggregation-induced emission (AIE)-based fluorescent molecules with photoresponsivity have been quickly developed and employed in the biomedical field. In this Review, photoresponsive AIE materials based on the inherent photochemical reactions are highlighted according to the photochemical pathways: photoisomerization, photocyclization, photodimerization, and multiple photoreactions. Following this, their biomedical applications are summarized and discussed, including photoactivatable bioimaging, diagnosis, and therapy. Finally, the challenges and future perspectives are presented.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504000 | PMC |
http://dx.doi.org/10.1021/cbmi.3c00038 | DOI Listing |
Eur J Med Chem
January 2025
Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Healthand, Department of Frontiers Science Center for Disease-related Molecular Network, Core Facilities, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Electronic address:
NEK2, a serine/threonine protein kinase, is integral to mitotic events such as centrosome duplication and separation, microtubule stabilization, spindle assembly checkpoint, and kinetochore attachment. However, NEK2 overexpression leads to centrosome amplification and chromosomal instability, which are significantly associated with various malignancies, including liver, breast, and non-small cell lung cancer. This overexpression could facilitate tumor development and confer resistance to therapy by promoting aberrant cell division and centrosome amplification.
View Article and Find Full Text PDFJ Phys Chem Lett
January 2025
Shanghai Key Laboratory of Magnetic Resonance, Institute of Magnetic Resonance and Molecular Imaging in Medicine, School of Physics and Electronic Science, East China Normal University, Shanghai 200062, P. R. China.
In traditional operations of all-solid-state lithium metal batteries (ASSLMBs), a small thin lithium metal circular disk is employed as a lithium metal anode (LMA). However, ASSLMBs with a circular-disk LMA often fail in <150 cycles with low capacity retention. In this work, we developed a new ring-shaped LMA to improve cyclability.
View Article and Find Full Text PDFMol Divers
January 2025
Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, S.A.S Nagar, Mohali, Punjab, 160062, India.
CD47, a cell surface protein, serves as a "don't eat me" signal that prevents immune cells from engulfing healthy cells upon its interaction with SIRPα. Cancer cells exploit this mechanism by overexpressing CD47 to evade immune destruction. Blocking the interaction between CD47 and its receptor, SIRPα, is a promising therapeutic strategy.
View Article and Find Full Text PDFMol Divers
January 2025
School of Biological & Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou, 310023, People's Republic of China.
The quinazoline scaffold serves as a fundamental framework, demonstrating potent anti-tumor activity. Employing the pharmacophore-based scaffold hopping principle, we successfully synthesized a series of FAK/PLK1 inhibitors incorporating the quinazoline scaffold. The synthesized compounds were characterized using H NMR, C NMR, and HRMS techniques.
View Article and Find Full Text PDFEur J Pediatr
January 2025
Infectious Diseases Unit, Department of Health Sciences, Anna Meyer Children's University Hospital, University of Florence, Florence, Italy.
Purpose: High-accuracy diagnostic screening tests for Mycobacterium tuberculosis (MTB) infection are required, primarily to detect patients with latent infections (LTBIs) in order to avoid their progression to active tuberculosis disease. The performance of the novel IGRA LIOFeron®TB/LTBI was evaluated in children. The originality of this test is the new MTB antigen contained (L-alanine dehydrogenase), identified as a tool to differentiate active TB from LTBI infection.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!