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Simultaneous Dehalogenation and Hydrogenation in Sonogashira Coupling. | LitMetric

Simultaneous Dehalogenation and Hydrogenation in Sonogashira Coupling.

Precis Chem

Department of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing, 401331, P.R. China.

Published: December 2023

AI Article Synopsis

  • - This study explores a new reaction in Sonogashira coupling where both dehalogenation and hydrogenation occur simultaneously, specifically using hexahalogenobenzenes (CX, where X = I or Br).
  • - Researchers synthesized a bulky terminal alkyne to analyze how different reaction conditions affect the DHH reaction, later testing a less hindered alkyne to see its impact on the process.
  • - The outcome produced two new aromatic polyynes, and their photophysical properties were analyzed, contributing valuable insights into the reactions involving sterically hindered alkynes and polyhalogenated aromatic compounds.

Article Abstract

We herein report a simultaneous dehalogenation and hydrogenation (DHH) reaction in Sonogashira coupling involving hexahalogenobenzene CX (X = I, Br), in which a halogen on the aryl polyhalide substrate was substituted by a hydrogen atom. First, a steric bulky terminal alkyne was designed and synthesized to study the influence of the reaction conditions (e.g., catalyst, solvent, temperature) and the halogens on the substrates CX on the DHH reaction. Moreover, based on the optimized conditions, a terminal alkyne with less steric hindrance was further synthesized to investigate the influence of alkyne on the DHH reaction. As a result, two aromatic polyynes and were obtained in the DHH process, and their photophysical properties were further studied and compared. The influence produced by the alkynes and aryl polyhalides substrate provide insights into Sonogashira coupling involving terminal alkyne with huge steric hindrance and polyhalogenated aromatic hydrocarbons.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503805PMC
http://dx.doi.org/10.1021/prechem.3c00093DOI Listing

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