Sustainable synthesis of silver nanoparticles from : antimicrobial, antioxidant and analysis for periodontal treatment.

Introduction: This study explores potential application of silver nanoparticles (AgNPs) to treat periodontal infection using leaf extract. The eco-friendly green synthesis process uses as a natural stabilizer and reducer, allowing AgNPs to be formed.

Methods: Experimental AgNPs were characterized through transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), Zeta potential, ultraviolet-visible spectroscopy (UV-Vis) etc. The antimicrobial, antioxidant potential of AgNPs was tested to identify its efficacy against periodontal infections.

Results And Discussion: AgNPs were found spherical, nanosized (86 nm), with negative surface charge (-26.9 mV). TEM study depicted clear formation of discrete nanosize particles with smooth surface texture. Results showed strong antibacterial and anti-oxidant action of experimental AgNPs, preventing biofilm growth and bacterial viability. A higher binding affinity was observed between Quercetin and the selected protein, which is implicated in bacterial growth and biofilm formation on teeth. The study suggests that derived AgNPs could be a safe, efficacious, and eco-friendly alternative in place of conventional therapies to treat periodontal infection. Future studies are however warranted.