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Function: _error_handler
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Filename: controllers/Detail.php
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Function: _error_handler
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Toxic air pollutants (TAPs) are a class of airborne chemicals known or suspected to cause serious health issues. This study, applying positive matrix factorization and inhalation unit risk estimates of TAPs, quantifies the changes in significant sources contributing to inhalation cancer risks (ICRs) from 2000 to 2020 in Hong Kong, China. Total ICR decreased from 1701 to 451 cases per million between 2000-2004 and 2016-2020, largely attributed to the reduction in diesel particulate matter (DPM), gasoline and solvent use-related volatile organic compounds (VOCs), and coal/biomass combustion-related polycyclic aromatic hydrocarbons and metal(loid)s. The regional contribution of VOCs associated with industrial and halogenated solvent sources increased substantially, representing the largest non-DPM ICR contributor (37%) in 2016-2020, stressing the need for a more comprehensive risk evaluation across the fast-growing and densely populated Greater Bay Area (GBA). ICRs in Hong Kong and the GBA will likely remain over 100 cases per million by 2050. The contributions to ozone formation potential of VOC/carbonyl sources were quantified, which show a notable shift from being solvent/gasoline-dominant in 2000-2004 to being more evenly shared by various sources in 2016-2020. Establishing a similar TAP monitoring network in the GBA is anticipated to provide the monitoring data needed to facilitate the development of more informed air quality management strategies.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504198 | PMC |
http://dx.doi.org/10.1021/envhealth.3c00209 | DOI Listing |
Cell Rep
December 2024
Center for Cell Lineage Technology and Engineering, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, China-New Zealand Belt and Road Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address:
Single-cell lineage tracing based on CRISPR-Cas9 gene editing enables the simultaneous linkage of cell states and lineage history at a high resolution. Despite its immense potential in resolving the cell fate determination and genealogy within an organism, existing implementations of this technology suffer from limitations in recording capabilities and considerable barcode dropout. Here, we introduce DuTracer, a versatile tool that utilizes two orthogonal gene editing systems to record cell lineage history at single-cell resolution in an inducible manner.
View Article and Find Full Text PDFAdv Sci (Weinh)
December 2024
Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, 510317, China.
Aneuploidy eggs are a common cause of human infertility, spontaneous abortion, or trisomy syndromes. The spindle assembly checkpoint (SAC) plays a crucial role in preventing aneuploidy in oocytes, yet it is unclear if additional mechanisms exist to ensure oocyte adherence to this checkpoint. It is now revealed that the microtubule-associated protein NUSAP can prevent oocytes from evading the SAC and regulate the speed of the cell cycle.
View Article and Find Full Text PDFInt J Nanomedicine
December 2024
Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, 999077, People's Republic of China.
Background: The lymphatic system is the major route of cancer metastasis, and sentinel lymph nodes (SLNs) are the first station for the spread of cancer cells. Accurate identification of SLNs by tracers during surgery is crucial for SLN biopsy and lymphadenectomy. However, conventional monomodal tracers such as blue dyes and carbon nanoparticles often induce a misjudgment of SLNs and thus are still unsatisfying for clinical applications.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
Chinese Academy of Sciences, State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350608, P. R. China., CHINA.
Coordination polymers (CPs) are promising for direct X-ray detection and imaging owing to higher designability and outstanding stability, however, it remains a challenge to achieve highly X-ray detection performance, particularly both high sensitivity and low detection limit at the same operating voltage. Herein, we construct a new conjugated CP {[Co(BPTTz)(DIPA)] DMA}n (1, BPTTz = 2,5-bis(pyridine-4-yl)thiazolo[5,4-d]thiazole, H2DIPA = 2,5-diiodoterephthalic acid, DMA = N, N'-dimethylacetamide), with multi-channel charge transfer by regulating the linker mediated electronic-state, which reduces carrier losses resulting from recombination or quenching, enhances the efficiency of charge separation and transfer, thus further optimizes X-ray detection performance. The semiconductor prepared based on this strategy achieves record values including the highest mobility-lifetime product (μτ, 8.
View Article and Find Full Text PDFMar Pollut Bull
December 2024
Tianjin Key Laboratory for Marine Environmental Research and Service, School of Marine Science and Technology, Tianjin University, Tianjin 300072, China. Electronic address:
We studied the characteristics of plankton community and its response to water environmental factors at the early stage of COVID-19 outbreak (2019-2020) in the Tianjin coastal waters of Bohai Bay. The water quality showed a good trend during this period, due to the reduction of pollution brought by the runoff rivers and water exchange driven by the circulation. In the survey area, 68 species of diatomata and dinoflagellata phytoplankton were found, where diatomata was the dominant population.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!