Microsporidia are common natural pathogens of the nematode . Infection of by the microsporidian species leads to induction of the Intracellular Pathogen Response (IPR), including transcriptional upregulation of 26 genes. The divergent ' ' sequence signature is conserved with humans, but PALS proteins have unknown biochemical functions. So far, none of the 26 induced genes have a demonstrated role in immunity. Here, we use RNAseq data, RNA interference, and CRISPR/Cas9 mutant analysis to identify the -induced gene as an immune gene that provides defense against microsporidia infection in .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519727 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.001325 | DOI Listing |
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