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Deletion of bZIP Transcription Factor Reveals Specialized Metabolites Potentially Regulating Stress Response in .
J Fungi (Basel)
January 2025
State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Fungal secondary metabolism (SM) is highly correlated with physiological processes that are typically regulated by pleiotropic regulators. In this study, we purposefully altered , a crucial regulator associated with oxidative stress in CGMCC 3.1066.
View Article and Find Full Text PDFIdentification and characterization of multiple novel viruses in fecal samples of cormorants.
Front Vet Sci
January 2025
Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Introduction: Cormorants, as protected wild animals by the State Forestry Administration of China, have a broad distribution across China. Previous studies have shown that they can be infected with multiple viruses in the , , , and families. There is limited knowledge about the other viruses that cormorants may carry and infect.
View Article and Find Full Text PDFEfficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity.
Front Endocrinol (Lausanne)
January 2025
Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD, United States.
Recombinant human IGF-1 is used to treat severe primary IGF-1 deficiency, but this treatment requires twice-daily injection, often does not fully correct the growth deficit, and has important off-target effects. We therefore sought to target IGF-1 to growth plate cartilage by generating fusion proteins combining IGF-1 with single-chain human antibody fragments that target matrilin-3, a cartilage matrix protein. We previously showed that this cartilage-targeting IGF-1 fusion protein (CV1574-1) promoted growth plate function in a GH-deficient (lit) mouse model.
View Article and Find Full Text PDFOsWRKY26 negatively regulates bacterial blight resistance by suppressing expression.
Front Plant Sci
January 2025
Graduate School of Green-Bio Science, Kyung Hee University, Yongin, Republic of Korea.
Plants are susceptible to infection by various pathogens with high epidemic potential. pv () causes bacterial blight in rice, one of the most significant diseases in both temperate and tropical regions. In this study, we report the identification and characterization of , a sucrose-inducible transcription factor, that plays a role in the plant defense responses following infection.
View Article and Find Full Text PDFPRA-MutPred: Predicting the Effect of Point Mutations in Protein-RNA Complexes Using Structural Features.
J Chem Inf Model
January 2025
Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, 600036 Tamil Nadu, India.
Interactions between proteins and RNAs are essential for the proper functioning of cells, and mutations in these molecules may lead to diseases. These protein mutations alter the strength of interactions between the protein and RNA, generally described as binding affinity (Δ). Hence, the affinity change upon mutation (ΔΔ) is an important parameter for understanding the effect of mutations in protein-RNA complexes.
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