AI Article Synopsis
- * Factors influencing the severity of injury include the maturity of the infant, the nature of the hypoxia-ischaemia exposure, and complications like impaired placental function and fetal growth restriction, along with socio-economic factors.
- * The review highlights the complex role of chorioamnionitis in neonatal injury and suggests that advancements in fetal monitoring could lead to better identification of injury risks and opportunities for preventive treatments before and after birth.
Article Abstract
Neonatal encephalopathy remains a major contributor to death and disability around the world. Acute hypoxia-ischaemia before, during or after birth creates a series of events that can lead to neonatal brain injury. Understanding the evolution of injury underpinned the development of therapeutic hypothermia. This review discusses the determinants of injury, including maturity, the pattern of exposure to HI, impaired placental function, often associated with fetal growth restriction and in the long-term, socio-economic deprivation. Chorioamnionitis has been associated with the presence of NE, but it is important to note that experimentally, inflammation can either sensitize to greater neural injury after HI or alleviate injury, depending on its precise timing. As fetal surveillance tools improve it is likely that improved detection of specific pathways will offer future opportunities for preventive and reparative interventions in utero and after birth.
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| http://dx.doi.org/10.1016/j.siny.2024.101542 | DOI Listing |
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