Int J Biol Macromol
Department of Stomatology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China. Electronic address:
Published: December 2024
Achieving desirable clinical outcomes is difficult given the rising number of cases and mortality of oral squamous cell carcinoma. Consequently, developing an efficient drug delivery system for managing cancer progression and metastasis with relatively low toxicity has proven to be highly promising. Initially, carboxymethyl chitosan was covalently modified and partially substituted with folic acid, and subsequently encapsulated as a shell to deliver carboxylated multiwalled carbon nanotubes and their coupled baicalin to form carboxymethyl chitosan-modified folate-targeted carbon nanotubes-baicalein complexes. The impact on the normal cell line HOK and the oral squamous cell carcinoma cell line CAL27 was assessed using CCK8, live-dead cell assay, colony formation assay, flow cytometry, wound healing assay, and transwell migration and invasion assays. These analyses confirmed that the complexes induced apoptosis in cancer cells and reduced the migration and invasion of CAL27 cells. Additionally, the complexes demonstrated enhanced biosafety, significantly inhibited the growth of xenograft tumors and tissue metastasis, and altered the expression of proteins associated with epithelial-mesenchymal transition. The results mentioned above imply that the complexes may offer novel applications and serve as an effective strategy for preventing cancer spread and metastasis.
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http://dx.doi.org/10.1016/j.ijbiomac.2024.136896 | DOI Listing |
Int J Biol Macromol
December 2024
Department of Stomatology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, China. Electronic address:
Achieving desirable clinical outcomes is difficult given the rising number of cases and mortality of oral squamous cell carcinoma. Consequently, developing an efficient drug delivery system for managing cancer progression and metastasis with relatively low toxicity has proven to be highly promising. Initially, carboxymethyl chitosan was covalently modified and partially substituted with folic acid, and subsequently encapsulated as a shell to deliver carboxylated multiwalled carbon nanotubes and their coupled baicalin to form carboxymethyl chitosan-modified folate-targeted carbon nanotubes-baicalein complexes.
View Article and Find Full Text PDFEur J Dent
July 2024
Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
Objective: The aim of this article was to evaluate the effects of modifying glass ionomer cement (GIC) with carboxymethyl chitosan (CMC) on surface morphology and remineralization outcomes by examining dentin morphology and calcium ion composition changes.
Materials And Methods: Thirty holes in a cylindrical acrylic mold were filled with three groups of restorative materials: GIC, GIC modified with CMC (GIC-CMC) 5%, and GIC-CMC10%. The surface morphology of each group's materials was observed using scanning electron microscopy (SEM).
Int J Biol Macromol
August 2024
Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing 400045, PR China.
This study synthesized a carboxymethyl chitosan-modified bimetallic Co/Zn-ZIF (CZ@CMC) with strong hydrophilicity and adsorption performance via the one-pot method. Tetracycline hydrochloride (TCH) was used as the model contaminant to evaluate the adsorption and peroxymonosulfate (PMS) activation properties of CZ@CMC. Mechanism showed that the adsorption behavior occurred through pore filling, electrostatic attraction, surface complexation, hydrogen bonding, and π-π stacking.
View Article and Find Full Text PDFCarbohydr Polym
July 2024
College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology College, Jilin 132101, China. Electronic address:
To alleviate skull defects and enhance the biological activity of taxifolin, this study utilized the thin-film dispersion method to prepare paclitaxel liposomes (TL). Thiolated chitosan (CSSH)-modified TL (CTL) was synthesized through charge interactions. Injectable hydrogels (BLG) were then prepared as hydrogel scaffolds loaded with TAX (TG), TL (TLG), and CTL (CTLG) using a Schiff base reaction involving oxidized dextran and carboxymethyl chitosan.
View Article and Find Full Text PDFMolecules
March 2024
Tianjin Key Laboratory of Food Science and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.
The oral delivery strategy of natural anti-oxidant and anti-inflammatory agents has attracted great attention to improve the effectiveness of ulcerative colitis (UC) treatment. Herein, we developed a novel orally deliverable nanoparticle, carboxymethyl chitosan (CMC)-modified astaxanthin (AXT)-loaded nanoparticles (CMC-AXT-NPs), for UC treatment. The CMC-AXT-NPs were evaluated by appearance, morphology, particle size, ζ-potential, and encapsulation efficiency (EE).
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