AI Article Synopsis
- - Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat to global health, with similar cases reported in Hainan.
- - Researchers isolated a bacteriophage named vB_SauP_L1 from local sources that can effectively kill 18 out of 35 MRSA strains, showing good growth and environmental resilience.
- - Genomic analysis of vB_SauP_L1 revealed a 17,114 bp linear double-stranded DNA with no virulent or antibiotic resistance genes, suggesting it could be a promising option for preventing and treating MRSA infections.
Article Abstract
Methicillin resistance Staphylococcus aureus (MRSA) is currently threatening global public health, and a similar issue was encountered in Hainan. For establishing a promising alternative therapeutic option, a phage with the capacity of lysing 18 out of 35 MRSA clinical isolates was recovered from domestic natural sources, which was termed as vB_SauP_L1 due to its morphology and genomic similarity with Rountreeviridae. Satisfactory proliferation rate and environmental tolerance were demonstrated by subsequent infectious properties tests and stability assessments. Sequencing revealed that its genome consisted of a linear double-stranded DNA of 17,114 bp, in which neither virulent nor resistant gene was detected, indicating its potential in MRSA prevention and treatment.
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| http://dx.doi.org/10.1016/j.virol.2024.110264 | DOI Listing |
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