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Agreement Between Sepsis-2 and Sepsis-3 Definitions Among Patients Admitted to the Intensive Care Unit.
Ann Am Thorac Soc
October 2024
UCSF, Medicine, San Francisco, California, United States.
Characteristics and Outcomes of Obstetric Sepsis by Three Sets of Clinical Diagnostic Criteria: A Retrospective Study.
Am J Perinatol
May 2024
Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan.
Article Synopsis
- Pregnancy-related mortality in the U.S. is notably high, and sepsis contributes significantly to these deaths. The study compares three sepsis criteria (Sepsis-2, Sepsis-3, and CMQCC) to evaluate their effectiveness and patient outcomes.
- Analysis of data from the University of Michigan Medical Center shows that while Sepsis-2 identified the majority of patients, there was weak agreement among all three criteria, indicating inconsistencies in diagnosing sepsis.
- The findings suggest that those diagnosed using CMQCC criteria had worse health profiles and higher mortality rates, highlighting the need for improved diagnostic criteria in managing sepsis during pregnancy.
Predictive factors for sepsis by carbapenem resistant Gram-negative bacilli in adult critical patients in Rio de Janeiro: a case-case-control design in a prospective cohort study.
Antimicrob Resist Infect Control
August 2020
Laboratório de Genética Molecular de Microrganismos, Instituto Oswaldo Cruz, Oswaldo Cruz Foundation (IOC/FIOCRUZ), Rio de Janeiro, RJ, Brazil.
Background: Studies have investigated risk factors for infections by specific species of carbapenem-resistant Gram-negative bacilli (CR-GNB), but few considered the group of GNB species and most of them were performed in the setting of bacteremia or hospital infection. This study was implemented to identify risk factors for sepsis by CR- and carbapenem-susceptible (CS) GNB in intensive care unit (ICU) patients to improve management strategies for CR-GNB sepsis.
Methods: We developed a case-case-control study from a prospective cohort of patients with systemic inflammatory response syndrome (SIRS), sepsis-2 or sepsis-3 criteria in which blood and other sample cultures were collected and antimicrobial therapy was instituted, in an adult clinical-surgical ICU, at tertiary public hospital in Rio de Janeiro, from August 2015 through March 2017.
A Comparison of Sepsis-2 (Systemic Inflammatory Response Syndrome Based) to Sepsis-3 (Sequential Organ Failure Assessment Based) Definitions-A Multicenter Retrospective Study.
Crit Care Med
September 2020
Department of Cardiac Surgery, University of Massachusetts, Springfield, MA.
Objectives: Recently, the definition of sepsis has changed from a physiologic derangement (Sepsis-1 and -2) to organ dysfunction (Sepsis-3) based. We sought to determine the concordance between the different sepsis phenotypes and how that affected mortality.
Design: Retrospective, multicenter study.
Monocyte distribution width enhances early sepsis detection in the emergency department beyond SIRS and qSOFA.
J Intensive Care
May 2020
7Beckman Coulter, Inc., Miami, FL USA.
Background: The initial presentation of sepsis in the emergency department (ED) is difficult to distinguish from other acute illnesses based upon similar clinical presentations. A new blood parameter, a measurement of increased monocyte volume distribution width (MDW), may be used in combination with other clinical parameters to improve early sepsis detection. We sought to determine if MDW, when combined with other available clinical parameters at the time of ED presentation, improves the early detection of sepsis.
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