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Dupilumab is Efficacious in Young Children with Atopic Dermatitis Regardless of Type 2 Comorbidities. | LitMetric

AI Article Synopsis

  • The study investigates how type 2 comorbidities like asthma, allergic rhinitis, and food allergies affect the treatment response to dupilumab in young children with atopic dermatitis.
  • In a trial involving children aged 6 months to 5 years, results showed that those treated with dupilumab had significantly better outcomes compared to those on placebo, regardless of comorbidities.
  • Overall, the treatment was found to be safe and effectively improved symptoms of atopic dermatitis in children, supporting its use in those with and without type 2 inflammatory conditions.

Article Abstract

Introduction: Patients with atopic dermatitis (AD) often have other comorbid type 2 inflammatory conditions. The aim of this study was to evaluate the impact of type 2 comorbidities on the response to and safety of dupilumab in young children with AD.

Methods: LIBERTY AD PRESCHOOL part B was a randomized, placebo-controlled trial in children aged 6 months to 5 years with moderate-to-severe AD. In this post hoc analysis, patients were stratified by the presence or absence of caregiver-reported selected type 2 comorbidities at baseline: asthma, allergic rhinitis (AR), and food allergies (FAs).

Results: At week 16, significantly more patients receiving dupilumab versus placebo, with or without asthma and AR, achieved an Investigator's Global Assessment (IGA) score of 0/1 and a ≥ 75% improvement in Eczema Area and Severity Index (all p < 0.05). Significantly more patients receiving dupilumab versus placebo with FAs and numerically more patients without FAs achieved an IGA score of 0/1 (p = 0.0007 and p = 0.06). Numerically more patients receiving dupilumab versus placebo with asthma and significantly more patients without asthma achieved a ≥ 4-point reduction in the weekly average of daily score on the Worst Scratch/Itch Numeric Rating Scale (WSI-NRS) (p = 0.6 and p < 0.0001). Additionally, significantly more patients receiving dupilumab versus placebo with or without AR (p = 0.008 and p < 0.0001) and with or without FAs (p = 0.0002 and p = 0.004) achieved a ≥ 4-point reduction in the weekly average of daily score on the WSI-NRS. Overall safety was consistent with the known dupilumab safety profile.

Conclusions: Dupilumab treatment improves AD signs and symptoms in children aged 6 months to 5 years with and without type 2 comorbidities such as asthma, AR, and FAs.

Trial Registration: ClinicalTrials.gov registration number NCT03346434.

Infographic: Do type 2 comorbidities impact the response to dupilumab in children with atopic dermatitis? (MP4 103,451 KB).

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550244PMC
http://dx.doi.org/10.1007/s12325-024-02998-4DOI Listing

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