AI Article Synopsis
- The VISTA Enhancer Browser has been updated to include over 4,500 transgenic enhancer assays from mouse embryos, significantly expanding its database from the original 250 experiments since 2007.
- It now contains more than 23,500 images and provides detailed information on enhancer activities during various stages of embryonic development, including data on both human disease-related and synthetic genetic variants.
- The updated resource includes manually curated results from thousands of experiments and comparisons between different genetic alleles, making it essential for research in human genetics, gene regulation, and developmental biology.
Article Abstract
Regulatory elements (enhancers) are major drivers of gene expression in mammals and harbor many genetic variants associated with human diseases. Here, we present an updated VISTA Enhancer Browser (https://enhancer.lbl.gov), a database of transgenic enhancer assays conducted in developing mouse embryos in vivo. Since the original publication in 2007, the database grew nearly 20-fold from 250 to over 4500 experiments and currently harbors over 23 500 images. The updated database provides structured information on experiments conducted at different stages of embryonic development, including enhancer activities of human pathogenic and synthetic variants and sequences derived from a variety of species. In addition to manually curated results of thousands of individual experiments, the new database also features hundreds of manually curated comparisons between alleles. The VISTA Enhancer Browser provides a crucial resource for study of human genetic variation, gene regulation and developmental biology.
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| http://dx.doi.org/10.1093/nar/gkae940 | DOI Listing |
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