SpliceMutr shows that splicing antigenicity changes in response to ICI therapies and that native modulation of the splicing machinery through mutations increases the contribution of splicing to the neoantigen load of some The Cancer Genome Atlas cancer subtypes. Future studies of the relationship between splicing antigenicity and immune checkpoint inhibitor response pan-cancer are essential to establish the interplay between antigen heterogeneity and immunotherapy regimen on patient response.
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| http://dx.doi.org/10.1158/2767-9764.CRC-23-0309 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648103 | PMC |
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