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Pregabalin and gabapentin-induced heart failure.
Cardiol J
October 2024
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, United States.
Gabapentin-Induced Myoclonus in a Patient With Chronic Kidney Disease.
Cureus
October 2023
Internal Medicine, State University of New York Downstate Health Sciences University, Brooklyn, USA.
Gabapentin contains a cyclohexyl group and is a form of gamma-aminobutyric acid (GABA). Despite its name, gabapentin does not affect the inhibitory neurotransmitter GABA or its receptors. Instead, it acts as a ligand, binding strongly to the α2δ (Ca) channel subunit and interfering with its regulatory function and the release of excitatory neurotransmitters.
View Article and Find Full Text PDFGabapentin-Induced Overflow Urinary Incontinence: A Case Report and Review of the Literature.
J Pain Palliat Care Pharmacother
June 2023
Sarah Masri, PharmD, Don Scigliano, PharmD, and Katherine M. Juba, PharmD, are with the Department of Pharmacy Practice, St. John Fisher University, Rochester, NY, USA.
Gabapentin (GBP) is a structural analog of gamma-aminobutyric acid (GABA) that is commonly used in palliative care for symptom management indications including neuropathic pain syndromes, hiccups, cough, and anxiety. An uncommon adverse effect of GBP is urinary incontinence (UI). We report the case of a 61-year-old male with metastatic non-small cell lung cancer who developed probable overflow UI while receiving 1200 mg/day of GBP for chemotherapy-induced peripheral neuropathy.
View Article and Find Full Text PDFNegative myoclonus induced by gabapentin and pregabalin: A case series and systematic literature review.
J Neurol Sci
November 2017
Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, South Korea. Electronic address:
Introduction: Negative myoclonus is a jerky, brief, and sudden interruption of voluntary muscle contraction. Although gabapentin and pregabalin have been reported to induce positive myoclonus in some patients with impaired renal function, there are only a few studies describing pregabalin- or gabapentin-induced negative myoclonus. This study reviewed patients who had developed pregabalin- or gabapentin-induced negative myoclonus.
View Article and Find Full Text PDFGabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms.
Neuropharmacology
June 2014
Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. Electronic address:
Gabapentin has shown to be effective in animals and humans with acute postoperative and chronic pain. Yet the mechanisms by which gabapentin reduces pain have not been fully addressed. The current study performed in vivo microdialysis in the locus coeruleus (LC) in normal and spinal nerve ligated (SNL) rats to examine the effect of gabapentin on extracellular glutamate concentration and its mechanisms of action with focus on presynaptic GABA-B receptors, astroglial glutamate transporter-1 (GLT-1), and interactions with α2δ subunits of voltage-gated Ca(2+) channels and endogenous noradrenaline.
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