AI Article Synopsis
- Brain metastasis from cervical cancer is rare and has a poor prognosis, with no established effective treatments known until recently.
- A 50-year-old patient with cervical cancer developed multiple metastases and initially received various therapies, but with limited success.
- After starting treatment with the PD-1/CTLA-4 inhibitor cadonilimab, the patient showed significant improvement, achieving a very good partial response and surviving over 18 months after the brain metastasis diagnosis.
Article Abstract
Background: Brain metastasis (BM) from cervical cancer (CC) is extremely rare. The prognosis of BM is poor. To our knowledge, no satisfactory therapeutic and standard effective treatments have been established. Immune checkpoint inhibitors (ICIs) treatment is emerging as a promising treatment in recurrence and metastasis(B/M) cervical cancer in recent years.
Case: We present a 50-year-old patient with CC who developed multiple metastasis (lung, brain and skin) 2 years after postoperative chemoradiotherapy. She received palliative therapy included chemotherapy, resection and stereotactic radiosurgery of BM with poor response. Then, the patient received second-line palliative monotherapy with a PD-1/CTLA-4 inhibitor(cadonilimab) and achieved clinical very good partial response (VGPR), a progression-free survival (PFS) of 14 months and overall survival of more than 18 months since BM.
Conclusion: We report a case of cervical cancer with multiple metastasis receiving cadonilimab and achieved considerable response and survival benefit.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513290 | PMC |
| http://dx.doi.org/10.3389/fimmu.2024.1434697 | DOI Listing |
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