Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multisystem condition destined to become pandemic in the coming decades. This study aimed at evaluating the economic impact of MASLD in the Italian population from the Italian National Healthcare Service (NHS) perspective.
Methods: The economic impact of the MASLD was assessed by developing a calculation model in Microsoft Excel from the Italian NHS perspective, considering healthcare resources and direct costs. The target population was based on the prevalence data. Through a literature search, complications of MASLD were identified, including MASH, with relative risk of evolution into CC, DCC, HCC, T2DM, cardiovascular diseases, in particular AMI and stroke, CKD, and CRC. The differential impact between complication development in the population with MASLD and the same sample size population without-MASLD was evaluated. Differential risk data, mortality rates, and event unit costs were drawn from the published international literature. Frequency and cost data were applied to the total target population, the total annual costs and mortality data, referring to the two arms, were then calculated, and the differential value was obtained.
Results: Based on an estimated 11,546,370 MASLD target population, an annual illness impact of €12,251,631,822 was calculated, corresponding to a difference of €7,731,674,054 compared with the same sample size without MASLD. Moreover, the MASLD population is expected to experience 13,438 additional deaths annually.
Conclusion: The growing epidemiological impact of MASLD and its complications represent a huge economic burden for healthcare services worldwide. An integrated approach, including changes in lifestyle behaviors, will be the first step. Specific drugs for MASLD are not yet available; however, studies are underway, and combined pharmaceutical therapies may be an inevitable choice to achieve adequate control of MASLD and its complications.
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http://dx.doi.org/10.2147/CEOR.S472446 | DOI Listing |
PLoS One
January 2025
Department of Fish and Wildlife Conservation, Virginia Tech, Blacksburg, VA, United States of America.
Rabies is a zoonotic infectious disease of global distribution that impacts human and animal health. In rural Latin America, rabies negatively impacts food security and the economy due to losses in livestock production. The common vampire bat, Desmodus rotundus, is the main reservoir and transmitter of rabies virus (RABV) to domestic animals in Latin America.
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January 2025
Faculty of Social and Behavioural Sciences, Utrecht University, Utrecht, The Netherlands.
Anti-bias interventions do not always have the intended results and can even backfire. In light of research on the psychology of morality, we examined whether confronting people with evidence of their own (group's) bias causes a (psychophysiological) threat response, and how to overcome this. We focused on an intervention addressing gender bias in teacher evaluations.
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January 2025
College of Economics and Management, Southwest University, Chongqing, China.
The nexus between the business environment and high-quality economic development is pivotal for fostering sustainable growth. This study delves into their interrelationship, recognizing its profound practical significance. We have developed a comprehensive index system to evaluate high-quality economic development, encompassing four key dimensions: green development quality, robust economic growth, innovation dynamics, and equitable societal benefits.
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January 2025
School of Finance, Lanzhou University of Finance and Economics, Lanzhou, PR China.
Digitalization has penetrated into every aspect of life. However, research on the mechanisms through which digitalization affects the equalization of basic public services, as well as the heterogeneity of its impact on different fields of these services, is still insufficient. Based on the panel data of 30 provincial-level administrative regions in China from 2013 to 2023, this paper studies the mechanism and heterogeneity of the impact of digital development on the equalization of basic public services.
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