AI Article Synopsis

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is a rising health issue in Italy, with the study evaluating its economic burden on the National Healthcare Service.
  • Utilizing an Excel model, researchers compared healthcare costs and complications associated with MASLD against a similar population without it, revealing significant financial and mortality impacts.
  • The study estimates that MASLD could cost the Italian healthcare system over €12 billion annually and result in approximately 13,438 extra deaths, highlighting the need for lifestyle changes and future pharmaceutical interventions.

Article Abstract

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multisystem condition destined to become pandemic in the coming decades. This study aimed at evaluating the economic impact of MASLD in the Italian population from the Italian National Healthcare Service (NHS) perspective.

Methods: The economic impact of the MASLD was assessed by developing a calculation model in Microsoft Excel from the Italian NHS perspective, considering healthcare resources and direct costs. The target population was based on the prevalence data. Through a literature search, complications of MASLD were identified, including MASH, with relative risk of evolution into CC, DCC, HCC, T2DM, cardiovascular diseases, in particular AMI and stroke, CKD, and CRC. The differential impact between complication development in the population with MASLD and the same sample size population without-MASLD was evaluated. Differential risk data, mortality rates, and event unit costs were drawn from the published international literature. Frequency and cost data were applied to the total target population, the total annual costs and mortality data, referring to the two arms, were then calculated, and the differential value was obtained.

Results: Based on an estimated 11,546,370 MASLD target population, an annual illness impact of €12,251,631,822 was calculated, corresponding to a difference of €7,731,674,054 compared with the same sample size without MASLD. Moreover, the MASLD population is expected to experience 13,438 additional deaths annually.

Conclusion: The growing epidemiological impact of MASLD and its complications represent a huge economic burden for healthcare services worldwide. An integrated approach, including changes in lifestyle behaviors, will be the first step. Specific drugs for MASLD are not yet available; however, studies are underway, and combined pharmaceutical therapies may be an inevitable choice to achieve adequate control of MASLD and its complications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514691PMC
http://dx.doi.org/10.2147/CEOR.S472446DOI Listing

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