AI Article Synopsis
- The expression of ABO (ABH) antigens on red blood cells and the secretion of ABH substances in bodily fluids are controlled by different genes, with the Secretor gene determining secretor status.
- A study conducted on 318 blood donors in South India from Jan 2020 to Dec 2021 found that 72% were secretors while 28% were nonsecretors, revealing a clear relationship between secretor status and Lewis phenotyping.
- The findings suggest that knowing the Lewis phenotype can help identify blood group secretor status, which is crucial for resolving discrepancies in ABO blood groups in medical settings.
Article Abstract
ABO (ABH) antigen expression on red cell antigens and secretion of ABH substances in body fluids are governed by different genes. The presence or absence of the Secretor gene is the basis of secretor status positivity and negativity, respectively. Determination of the secretor status has an essential role in the medical field. It was a prospective observational study to determine the association of secretor and nonsecretor status with Lewis phenotyping among voluntary blood donors. It was conducted from Jan 2020 to December 2021 at the Department of Transfusion Medicine in a tertiary care hospital in South India. Among 318 donors, secretors were 229 (72%), and nonsecretors were 89 (28%). The Lewis phenotype was consistent with secretor status, i.e., All Le (a-b +) were secretors accounting for 213 (66.9%), and All Le(a + b-) were nonsecretors accounting for 80(25.1%)donors. In the Le(a-b-) phenotype, 16(5.0%) were secretors with Se positivity but defective Lewis expression, and 9(2.8%) were nonsecretors with sese. Detection of Lewis phenotype indirectly reflects the blood group secretor status. Hence, in case of discrepancies in ABO blood groups, Bombay and Para Bombay groups, testing for Le(b) confirmation will be useful.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512930 | PMC |
| http://dx.doi.org/10.1007/s12288-024-01761-7 | DOI Listing |
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