AI Article Synopsis

  • - The study investigates the genetic diversity of potential malaria vaccine targets, PfMSP1 and PfMSP2, in P. falciparum from Vietnam, highlighting the challenges posed by global genetic variation in vaccine development.
  • - Researchers found that P. falciparum in Vietnam showed higher genetic homogeneity in pfmsp1 and pfmsp2 compared to other countries, with unique allele diversity patterns differing significantly from its Greater Mekong Subregion neighbors.
  • - Results suggest that geographic isolation and specific evolutionary pressures may have led to the genetic characteristics seen in Vietnam's P. falciparum population, indicating potential factors like bottleneck effects influencing its genetic makeup.

Article Abstract

Background: Plasmodium falciparum merozoite surface proteins 1 (PfMSP1) and 2 (PfMSP2) are potential candidates for malaria vaccine development. However, the genetic diversity of these genes in the global P. falciparum population presents a significant challenge in developing an effective vaccine. Hence, understanding the genetic diversity and evolutionary trends in the global P. falciparum population is crucial.

Methods: This study analyzed the genetic variations and evolutionary changes of pfmsp1 and pfmsp2 in P. falciparum isolates from the Central Highland and South-Central regions of Vietnam. DNASTAR and MEGA7 programs were utilized for analyses. The polymorphic nature of global pfmsp1 and pfmsp2 was also investigated.

Results: A total of 337 sequences of pfmsp1 and 289 sequences of pfmsp2 were obtained. The pfmsp1 and pfmsp2 from Vietnam revealed a higher degree of genetic homogeneity compared to those from other malaria-endemic countries. Remarkably, the allele diversity patterns of Vietnam pfmsp1 and pfmsp2 differed significantly from those of neighboring countries in the Greater Mekong Subregion. Declines in allele diversity and polymorphic patterns of Vietnam pfmsp1 and pfmsp2 were observed.

Conclusions: The Vietnam P. falciparum population might be genetically isolated from the parasite populations in other neighboring GMS countries, likely due to geographical barriers and distinct evolutionary pressures. Furthermore, bottleneck effects or selective sweeps may have contributed to the genetic homogeneity of Vietnam pfmsp1 and pfmsp2.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520470PMC
http://dx.doi.org/10.1186/s12879-024-10116-6DOI Listing

Publication Analysis

Top Keywords

pfmsp1 pfmsp2
28
falciparum population
16
merozoite surface
12
vietnam pfmsp1
12
surface protein
8
plasmodium falciparum
8
pfmsp1
8
pfmsp2
8
genetic diversity
8
global falciparum
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!