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Induction of Retinal Ischemia-Reperfusion Injury in a Mouse Eye Model.
J Vis Exp
December 2024
Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine;
Ischemia-reperfusion injuries are known to cause a range of retinal pathologies, including diabetic retinopathy, glaucoma, retinal vascular occlusions, and other vaso-occlusive conditions. This manuscript presents a method for inducing ischemia-reperfusion injury in a mouse model. The method utilized anterior chamber cannulation attached to a saline reservoir, generating hydrostatic pressure to raise the intraocular pressure to 90-100 mmHg.
View Article and Find Full Text PDFAn Atypical Finding of Peripheral Retinal Ischemia and Neovascularization in Neurofibromatosis Type 1: A Case Report.
Cureus
December 2024
Radiology Department, King Khaled Eye Specialist Hospital, Riyadh, SAU.
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic multisystem phakomatosis that can affect the skin, bones, and nervous system. NF1 typically presents with skin lesions, including freckles, café-au-lait macules, plexiform neurofibromas, and bony dysplasia, and is usually accompanied by a family history of the disorder. Ocular manifestations vary, but iris Lisch nodules and optic nerve gliomas are the most common features.
View Article and Find Full Text PDFTerson Syndrome in Two Infants: Case Report and Literature Review.
Cureus
December 2024
Department of Ophthalmology, King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, SAU.
We report the presentation and outcome of Terson syndrome in four eyes of two infants in a tertiary hospital in Saudi Arabia. This is a retrospective report of two infants with Terson syndrome due to accidental traumatic head injuries. Intraoperative screenshots of the posterior pole were taken for both cases.
View Article and Find Full Text PDFMultifaceted approach to evacuating multi-level premacular hemorrhage in a case of suspected Valsalva retinopathy - a case report.
BMC Ophthalmol
January 2025
Department of Retina and Vitreous, Narayana Nethralaya, #121/C, 1st R Block, Chord Road, Rajaji Nagar, Bengaluru, Karnataka, 560010, India.
Background: Accurate localization of premacular hemorrhages (PMHs) is crucial as treatment strategies vary significantly based on whether the hemorrhage resides within the vitreous gel, subhyaloid space, or beneath the internal limiting membrane (ILM). This report outlines the clinical features, diagnostic findings, and treatment outcomes in a patient diagnosed with a PMH secondary to suspected Valsalva retinopathy.
Methods: This is a retrospective interventional case report.
Article Synopsis
- The study investigates risk factors for proliferative vitreoretinopathy (PVR), a common complication after retinal detachment surgery.
- A large patient database was analyzed, identifying systemic (like age, gender, and smoking) and ocular (such as trauma and previous eye conditions) factors that correlate with increased PVR risk.
- The findings emphasize the importance of considering these risk factors in surgical planning and treatment to prevent PVR in patients with retinal detachment.
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