Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519665PMC
http://dx.doi.org/10.1038/s41392-024-02010-zDOI Listing

Publication Analysis

Top Keywords

miniproteins big
4
big impact
4
impact therapeutics
4
therapeutics autoimmune
4
autoimmune diseases
4
miniproteins
1
impact
1
therapeutics
1
autoimmune
1
diseases
1

Similar Publications

Protecting Encapsulin Nanoparticles with Cysteine-Knot Miniproteins.

Mol Pharm

August 2018

Laboratory for Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology , University of Twente, 7500 AE Enschede , The Netherlands.

A big hurdle for the use of protein-based drugs is that they are easily degraded by proteases in the human body. In an attempt to solve this problem, we show the possibility to functionalize TM encapsulin nanoparticles with an mEETI-II knottin miniprotein from the cysteine-stabilized knot class. The resulting particles did not show aggregation and retained part of their protease inhibitive function.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!