AI Article Synopsis
- Pancreatic adenocarcinoma (PDAC) is typically an immunologically 'cold' tumor, meaning it doesn't effectively recruit immune T cells for a response.
- Due to complex signaling pathways in its tumor microenvironment, most PDAC cases resist immune checkpoint blockade treatments.
- Recent advancements in genomics and proteomics are being employed to identify and manipulate these signaling pathways, aiming for combination immunotherapies that enhance T cell activity and ultimately eradicate PDAC tumors.
Article Abstract
Pancreatic adenocarcinoma (PDAC) is considered an immunologically 'cold' tumor that fails to attract or support effector T cells. Most PDACs are resistant to immune checkpoint blockade due to the complex signaling pathways that exist within its tumor microenvironment. Recent advances in genomic and proteomic technology advances are finally uncovering the complex inflammatory cellular and intercellular signals that require modulation and reprogramming. The goal is to 'turn up the heat' on PDACs with combination immunotherapies that incorporate T cell activating agents and immune modulatory agents, and successfully eradicate tumors. Here, we discuss progress and promising new research that is moving the field toward this goal.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529462 | PMC |
| http://dx.doi.org/10.1136/jitc-2024-010124 | DOI Listing |
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