AI Article Synopsis
- A study explored the potential of serum autotaxin (ATX) as a predictor for liver-related events (LRE) in patients with primary biliary cholangitis (PBC).
- During a median follow-up of 9.7 years of 190 untreated patients, those with ATX levels ≥1.086 mg/L experienced significantly more LRE compared to those with lower levels (33.3% vs 3.6%).
- The research suggests that ATX is a strong independent predictor for LRE, outperforming existing markers, and aligns with findings from a separate validation cohort of PBC patients.
Article Abstract
Introduction: A straightforward, reliable, and noninvasive method for predicting the development of liver-related events (LRE) in primary biliary cholangitis (PBC) has not been attained thus far. This study investigated whether serum autotaxin (ATX) could predict LRE in patients with PBC.
Methods: This retrospective multicenter investigation included 190 biopsy-proven untreated patients with PBC. All subjects were followed for at least 1 year, during which time the prevalence of LRE, including newly developing hepatocellular carcinoma, esophagogastric varices, ascites, and hepatic encephalopathy, was investigated in relation with ATX levels at the time of liver biopsy.
Results: During the median follow-up period of 9.7 years, LRE were observed in 22 patients (11.6%). The area under the receiver operating characteristic curve and cutoff value of serum ATX for predicting LRE were 0.80 and 1.086 mg/L, respectively. Patients with serum ATX ≥1.086 had a significantly higher cumulative incidence of LRE compared with patients with ATX < 1.086 (33.3% vs 3.6%, P < 0.00001). Notably, the predictive capability of ATX for LRE in patients with PBC surpassed that of FIB-4, ALBI, APRI, and Mac-2-binding protein glycan isomer. A multivariate Cox proportional hazards model revealed ATX as an independent associated factor for LRE (hazard ratio 6.24, 95% confidence interval 1.87-20.80, P = 0.003) along with Nakanuma stage (hazard ratio 2.75, 95% confidence interval 1.52-4.99, P < 0.001). These results were closely replicated in a serologically diagnosed PBC validation cohort (n = 32).
Discussion: Serum ATX levels may serve as a predictive marker for LRE in patients with PBC.
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| http://dx.doi.org/10.14309/ctg.0000000000000779 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671064 | PMC |
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- A study explored the potential of serum autotaxin (ATX) as a predictor for liver-related events (LRE) in patients with primary biliary cholangitis (PBC).
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