Sarcoidosis Mortality in North Carolina: Role of Region, Race, and Other Sociodemographic Variables.

Background: There is regional variability in sarcoidosis mortality across the United States. North Carolina ranks highly in sarcoidosis-related mortality, especially among African Americans (AA). We sought to determine any regional variability of sarcoidosis-related mortality and the relationship to sociodemographic determinants of health in North Carolina.

Methods: Counties in North Carolina were categorized into three distinct geographic regions: Western, Piedmont, and Eastern. Sarcoidosis deaths were stratified by region, race, and gender. We conducted a mapping and cluster analysis utilizing ArcGIS; Global and Local Moran's I was used to determine the prevalence, spatial autocorrelation, and clustering of mortality vis-a-vis various sociodemographic variables, occupational/environmental exposures, and levels of atmospheric particulate matter less than 2.5 microns in size (PM2.5). Multivariate linear regression with exposure limited to the county level was used to determine the relationship between sarcoidosis mortality and the variables of interest.

Results: Eastern North Carolina (ENC) had the highest age-adjusted sarcoidosis mortality rate (1.16/100,000 versus 0.49/100,000 in Piedmont and 0.32/100,000 in the Western region) with statistically significant high-high mortality clusters (P < .001 for Global Moran's I). Several sociodemographic and occupational factors (proportion of AA, obese adults, and individuals working in nature) were more prevalent in ENC. Region and proportion of AA were the significant mortality predictors in our multivariate analysis.

Limitations: This was a cross-sectional study with exposure limited to the county level. Associations do not imply causality and risks cannot be extrapolated to the individual level.

Conclusion: There is regional variability of sarcoidosis mortality in North Carolina. Eastern North Carolina had the highest mortality with high-high mortality clusters.