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"Blessed Be the Fruit" - The Contemporary Rise of Pronatalism.
N Engl J Med
October 2024
From Harvard Medical School (R.F., D.B.) and the Department of Obstetrics and Gynecology, Brigham and Women's Hospital (D.B.) - both in Boston.
Hippocampal Subfield Volumes Predict Disengagement from Maintenance Treatment in First Episode Schizophrenia.
Schizophr Bull
January 2023
Department of Psychiatry, NYU Langone Health, 1 Park Avenue, New York, NY, USA.
Objectives: Disengagement from treatment is common in first episode schizophrenia (FES) and is associated with poor outcomes. Our aim was to determine whether hippocampal subfield volumes predict disengagement during maintenance treatment of FES.
Methods: FES patients were recruited from sites in Boston, New York, Shanghai, and Changsha.
Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review.
Heliyon
January 2022
Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea.
Background: Cancer has become a significant concern in the medical sector with increasing disease complexity. Although some available conventional treatments are still a blessing for cancer patients, short-and long-term adverse effects and poor efficiency make it more difficult to treat cancer patients, demonstrating the need for new potent and selective anticancer drugs. In search of potent anticancer agents, naturally occurring compounds have always been admired due to their structural diversity, where Hesperetin (HSP) may be one of the potent candidates.
View Article and Find Full Text PDFEffect of citalopram on hippocampal volume in first-episode schizophrenia: Structural MRI results from the DECIFER trial.
Psychiatry Res Neuroimaging
June 2021
Department of Psychiatry, NYU Langone Health, 1 Park Avenue, New York, NY 10016, United States of America; Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, United States of America. Electronic address:
Hippocampal volume loss is prominent in first episode schizophrenia (FES) and has been associated with poor clinical outcomes and with BDNF genotype; antidepressants are believed to reverse hippocampal volume loss via release of BDNF. In a 12-month, placebo-controlled add-on trial of the antidepressant, citalopram, during the maintenance phase of FES, negative symptoms were improved with citalopram. We now report results of structural brain imaging at baseline and 6 months in 63 FES patients (34 in citalopram group) from the trial to assess whether protection against hippocampal volume loss contributed to improved negative symptoms with citalopram.
View Article and Find Full Text PDFPhytic acid: Blessing in disguise, a prime compound required for both plant and human nutrition.
Food Res Int
April 2021
Division of Crop Physiology, Biochemistry and Post-Harvest Technology, ICAR-Central Potato Research Insititute (ICAR-CPRI), Shimla-171001, Himachal Pradesh, India; Division of Plant Physiology, ICAR-Indian Agricultural Research Institute, New Delhi 110012, India. Electronic address:
Phytic acid (PA), [myo-inositol 1,2,3,4,5,6-hexakisphosphate] is the principal storage compound of phosphorus (P) and account for 65%-85% of the seeds total P. The negative charge on PA attracts and chelates metal cations resulting in a mixed insoluble salt, phytate. Phytate contains six negatively charged ions, chelates divalent cations such as Fe, Zn, Mg, and Ca rendering them unavailable for absorption by monogastric animals.
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