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L. Oligo-Polysaccharides (CIO) Exerts Antianxiety and Antidepressant Effects on Mice Experiencing Behavioral Despair and Chronic Unpredicted Mild Stress.
Foods
January 2025
Research Center for Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
L. oligo-polysaccharides (CIOs), obtained from L., is a mixture of oligosaccharides and polysaccharides.
View Article and Find Full Text PDFGinsenoside Rg1 enriches gut microbial indole-3-acetic acid to alleviate depression-like behavior in mice via oxytocin signaling.
Phytomedicine
December 2024
State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China; School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
Background And Purpose: Although a large collection of data has shown that ginsenosides, the major active ingredients from Ginseng, have neuroprotective and anti-depressant effect, the mechanism of action is incompletely understood. This study aims to elucidate the antidepressant mechanism of ginsenoside Rg1 (Rg1), a poorly absorbed ginsenoside, from the perspective of gut microbe to brain signaling.
Methods: A mouse model of depression was induced by unpredictable mild stress (UMS).
From Despair to Promise: The Dawn of Novel Treatment in IgA Nephropathy.
J Am Soc Nephrol
October 2024
Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Preventing social defeat stress-induced behavioural and neurochemical alterations by repeated treatment with a mix of , and standardized extracts.
Front Pharmacol
August 2024
Section of Pharmacology and Toxicology, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
Prolonged exposure to stress is a risk factor for the onset of several disorders. Modern life is burdened by a pervasive prevalence of stress, which represents a major societal challenge requiring new therapeutic strategies. In this context, botanical drug-based therapies can have a paramount importance.
View Article and Find Full Text PDFPrecarity and Hope at the Intersections of HIV and Cervical Cancer in a Johannesburg Clinic.
Med Anthropol
August 2024
Wits HIV and Reproductive Health Institute, University of Witwatersrand, Johannesburg, South Africa.
In a tragically ironic twist, antiretroviral therapy (ART) that promised an end to AIDS ushered in a syndemic of viral cancers, transforming hope to despair. In this article we draw from the illness narratives of HIV positive women attending a cervical cancer screening clinic in Johannesburg, South Africa, and chart their pathways from HIV to cancer, and their quest for treatment. Our interlocutors described protracted struggles to access surgical procedures to prevent the onset of cervical cancer.
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