Purpose: To study the clinical profile of patients with orbital myositis and their management modalities and predictive factors for recurrence.
Methods: The records of all consecutive patients diagnosed as having orbital myositis from 2010 to 2022 were reviewed. Patient demographics, presenting complaints, visual function, primary gaze deviation, and extraocular muscle involved were studied in the clinical profile. The radiological modalities and their management along with the recovery status and need for surgical intervention were documented.
Results: Fifty-two patients (55 eyes) (69% women) were diagnosed as having orbital myositis with a mean age of 36 ± 16 years presenting with periocular pain (55%) followed by diplopia (49%). Disease was unilateral in 94%. Sixty percent had ocular misalignment in primary gaze. The medial rectus was the most involved muscle (58%), with abduction limitation in 73%. Computed tomography (42%), magnetic resonance imaging (42%), and combined imaging (16%) were used in localizing the disease. Muscle biopsy was done in 38% of patients. Systemic immunomodulators were required in 16%. Strabismus surgery was planned in 15% of patients and done in 11%. Recurrence was noted in 43%. Abrupt cessation of steroids was a significant risk factor in recurrence of the disease ( = .046). Recovery was partial in 44% of patients and complete in 47%.
Conclusions: Systemic steroids with slow taper has satisfactory outcomes in orbital myositis. Patients refractory to treatment ideally should undergo biopsy and begin taking steroid-sparing agents. Once the disease is in remission, residual disease can be surgically treated for better functional outcome. .
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http://dx.doi.org/10.3928/01913913-20240926-04 | DOI Listing |
Int J Rheum Dis
January 2025
Department of Internal Medicine, Hedi Chaker University Hospital, Sfax, Tunisia.
Zhonghua Yan Ke Za Zhi
January 2025
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing100730, China.
Immune checkpoint inhibitors (ICI), as a new type of targeted therapeutic drugs, have demonstrated durable efficacy in cancer treatment. However, some patients receiving ICI treatment may be affected by immune-related adverse events (irAE). Compared with irAE in skin tissues, gastrointestinal system, etc.
View Article and Find Full Text PDFArch Soc Esp Oftalmol (Engl Ed)
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Servicio Oftalmología, Hospital Alfredo Espinosa, Urduliz, Bizkaia, Spain.
A 66-year-old woman presents with unilateral orbital inflammation of several years of evolution, initially classified as idiopathic orbital inflammatory disease (IOID) subtype myositis. She presented with pain, eyelid inflammation and significant elevation of intraocular pressure, as well as radiological signs of exophthalmos and superior rectus myositis. She was treated with corticosteroids, with partial response.
View Article and Find Full Text PDFNeurology
January 2025
From the Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Balkan Med J
January 2025
Department of Internal Medicine, Tokyo Metropolitan Matsuzawa Hospital, Setagaya, Tokyo, Japan
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