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Ruthenium(II) N-heterocyclic carbene polymer based sensors for detection of predatory drugs like ketamine and scopolamine. | LitMetric

AI Article Synopsis

  • There is a pressing need for a sensitive and quick method to detect ketamine and scopolamine, commonly used in drug-facilitated sexual assaults.
  • Researchers developed electrochemical sensors using N-heterocyclic carbene-coordinated ruthenium polymers combined with multi-walled carbon nanotubes, achieving high sensitivities for both drugs.
  • The sensors demonstrate remarkable selectivity and low detection limits, making them promising tools for on-site detection in forensic investigations of date rape drugs.

Article Abstract

The current demand in the field of abusive drug research is to have a highly sensitive and rapid method for detecting ketamine and scopolamine, which are frequently used in drug-facilitated sexual assaults administered beverages and food. We report here the first electrochemical sensors of N-heterocyclic carbene (NHC) coordinated ruthenium organometallic 1-dimensional polymers and their multi-walled carbon nano tube (MWCNT)-based composite for detecting ketamine and scopolamine. The preparation of ruthenium NHC organometallics and the MWCNT composite as sensors offers significant advantages for electrochemical applications, with enhanced sensitivities of 121.979 and 3.273 μA μM cm for ketamine and scopolamine, respectively, and selectivity in sensing applications. The complex-carbon composite sensor has a low limit of detection , 0.194 and 3.18 nM for ketamine and scopolamine identification, respectively. Alongside, the selectivity of the composite sensor was evaluated in the presence of other blood constituents, and the study evidenced remarkable discernment towards the title drugs. Furthermore, real-time analyses using the composite sensor demonstrated quantitative identification of ketamine and scopolamine. Therefore, this innovation has the potential to provide valuable tools for forensic investigations and address the urgent need for real-time detection of date rape drugs. This contribution demonstrates a robust proof-of-concept that emphasizes the importance of creating non-enzymatic, environmentally friendly, and cost-effective sensors for on-site sensing applications as point-of-care devices.

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Source
http://dx.doi.org/10.1039/d4dt02389gDOI Listing

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