Generalised cortical hyperostosis is a rare disease. In our own field it involves the lower jaw and the skull. Certain nerves, including the facial, may be compressed as a result. This condition behaves genetically in a recessive or dominant manner.
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Progression of Amyloid Accumulation in Late Adulthood Among People With Childhood-Onset Epilepsy.
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Departments of Child Neurology and General Practice, University of Turku and Turku University Hospital, Finland.
Background And Objectives: Previous research has demonstrated increased brain amyloid plaque load in individuals with childhood-onset epilepsy in late middle age. However, the trajectory of this process is not yet known. The aim of this study was to determine whether individuals with a history of childhood-onset epilepsy show progressive brain aging in amyloid accumulation in late adulthood (Turku Adult Childhood-Onset Epilepsy study, TACOE).
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January 2025
Department of Neuroscience, University of Padova, Padua, Italy.
In this study, we explored the biocultural mechanisms underlying ancient craft behaviours. Archaeological methods were integrated with neuroscience techniques to explore the impact on neuroplasticity resulting from the introduction of early pottery techniques. The advent of ceramic marked a profound change in the economy and socio-cultural dynamics of past societies.
View Article and Find Full Text PDFPrecision data-driven modeling of cortical dynamics reveals person-specific mechanisms underpinning brain electrophysiology.
Proc Natl Acad Sci U S A
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Department of Electrical & Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130.
Task-free brain activity affords unique insight into the functional structure of brain network dynamics and has been used to identify neural markers of individual differences. In this work, we present an algorithmic optimization framework that directly inverts and parameterizes brain-wide dynamical-systems models involving hundreds of interacting neural populations, from single-subject M/EEG time-series recordings. This technique provides a powerful neurocomputational tool for interrogating mechanisms underlying individual brain dynamics ("precision brain models") and making quantitative predictions.
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View Article and Find Full Text PDFLong-range inputome of prefrontal GABAergic interneurons in the Alzheimer's disease mouse.
Alzheimers Dement
January 2025
Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Sanya, China.
Introduction: Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by damage to cortical circuits. However, the mechanisms underlying AD-associated changes in long-range circuits remain poorly understood.
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