The accurate quantification of biomarkers is paramount in modern medicine, particularly in cancer where precise diagnosis is imperative for targeted therapy selection. In this paper we described a multiplexed analysis diagnostic approach based on cleavable MS-tagged antibodies. The technology uses MS-tag isotopologues and the sydnonimine-cyclooctyne click-and-release bioorthogonal reaction. In a proof of concept study, we demonstrated the potential of this approach for cancer cell immunoprofiling in culture cells, tissues and as well, thereby unveiling promising diagnostic avenues.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11499955 | PMC |
http://dx.doi.org/10.1039/d4sc04471a | DOI Listing |
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