AI Article Synopsis
- The study aimed to evaluate how certain estradiol (E2) levels predict the likelihood of developing gestational diabetes mellitus (GDM) in women receiving fresh embryo transfers.
- Results revealed that women with an E2/follicle (E2/F) ratio above 246.03 pg/ml had significantly lower rates of GDM and ovarian hyperstimulation syndrome (OHSS) compared to those below this threshold.
- The findings suggest that the E2/F ratio is a better indicator for predicting GDM risks than other E2-related measurements, emphasizing its importance in reproductive health assessments.
Article Abstract
Aims: To assess the predictive value of estradiol (E2) related parameters on the incidence of gestational diabetes mellitus (GDM) in women undergoing fresh embryo transfer.
Materials And Methods: A analysis of a prospective cohort study.
Results: We identified an optimal E2/follicle (E2/F) ratio threshold of 246.03 pg/ml on the day of human chorionic gonadotropin (hCG) administration. Women with an E2/F ratio exceeding this threshold had significantly lower rates of GDM (12.75% vs. 20.41%, P < 0.001) and ovarian hyperstimulation syndrome (OHSS) (11.75% vs. 15.48%, P = 0.03). Additional E2 parameters were also evaluated: baseline E2, E2 on hCG day, E2 increase, and E2 fold change. Lower GDM rates were observed in women with baseline E2 above 31.50 pg/ml (13.51% vs. 19.42%, P <0.01), E2 on hCG day above 3794.50 pg/ml (12.26% vs. 19.32%, P < 0.001), and E2 increase above 3771.50 pg/ml (12.24% vs. 19.28%, P < 0.001). There were no significant differences in OHSS rates for these additional E2 parameters. After adjusting for confounders, lower E2/F ratio (OR: 1.626, 95% CI: 1.229-2.150, P <0.01), E2 on hCG day (OR: 1.511, 95% CI: 1.133-2.016, P = 0.01), and E2 increase (OR: 1.522, 95% CI: 1.141-2.031, P <0.01) were identified as risk factors for GDM.
Conclusion: This study demonstrates that an E2/F ratio over 246.03 pg/ml is significantly associated with a reduced risk of both GDM and OHSS in women undergoing fresh embryo transfer, highlighting the E2/F ratio as a superior predictive biomarker compared to other E2-related parameters.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502309 | PMC |
| http://dx.doi.org/10.3389/fendo.2024.1465069 | DOI Listing |
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