AI Article Synopsis

  • Social vocal communication in mice involves specific brain regions that manage both expressing and receiving vocal signals, highlighting the importance of social context.
  • Researchers used a new behavioral method alongside microendoscopy to observe neuron activity in the posterior insula (pIns) of mice as they switched between vocalizing and listening.
  • Findings revealed that certain neurons in the pIns were active for vocalization prior to speaking and responded to social cues like female scents, indicating that this brain region plays a crucial role in processing communication signals.

Article Abstract

Socially effective vocal communication requires brain regions that encode expressive and receptive aspects of vocal communication in a social context-dependent manner. Here, we combined a novel behavioral assay with microendoscopy to interrogate neuronal activity in the posterior insula (pIns) in socially interacting mice as they switched rapidly between states of vocal expression and reception. We found that distinct but spatially intermingled subsets of pIns neurons were active during vocal expression and reception. Notably, pIns activity during vocal expression increased prior to vocal onset and was also detected in congenitally deaf mice, pointing to a motor signal. Furthermore, receptive pIns activity depended strongly on social cues, including female odorants. Lastly, tracing experiments reveal that deep layer neurons in the pIns directly bridge the auditory thalamus to a midbrain vocal gating region. Therefore, the pIns is a site that encodes vocal expression and reception in a manner that depends on social context.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507715PMC
http://dx.doi.org/10.1101/2024.10.15.618282DOI Listing

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