AI Article Synopsis
- * Lifespan studies of male and female AD mouse models show significant differences in survival rates based on sex and genetic background.
- * The findings highlight the importance of including both sexes in research to better understand and treat Alzheimer's disease.
Article Abstract
Alzheimer's disease (AD) disproportionately affects women, yet most preclinical research studies are male-centric. We performed lifespan analyses of male and female AD mouse models (APP/PS1 and APP) and their shared genetic background control (C57BL/6). Survival curves support significant sex differences between within genotypes. Minimal longevity revealed increased age in male APP/PS1, and decreased age in APP mice. Maximal longevity revealed an increased average age in males. Furthermore, median lifespan differed between sex and genotype. This study supports sexual dimorphic survival in two mouse models of AD, emphasizing the need to examine mechanisms and treatments in both sexes.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507819 | PMC |
| http://dx.doi.org/10.1101/2024.10.15.618508 | DOI Listing |
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