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Synthetic mycolates derivatives to decipher protein mycoloylation, a unique post-translational modification in bacteria.
J Biol Chem
January 2025
Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198, Gif-sur-Yvette, France. Electronic address:
Protein mycoloylation is a newly characterized post-translational modification (PTM) specifically found in Corynebacteriales, an order of bacteria that includes numerous human pathogens. Their envelope is composed of a unique outer membrane, the so-called mycomembrane made of very-long chain fatty acids, named mycolic acids. Recently, some mycomembrane proteins including PorA have been unambiguously shown to be covalently modified with mycolic acids in the model organism Corynebacterium glutamicum by a mechanism that relies on the mycoloyltransferase MytC.
View Article and Find Full Text PDFMolecular dynamics simulation dataset for SiO-BO-(1--)NaO glasses.
Data Brief
February 2025
Université Paris-Saclay, CEA, CNRS, SPEC, 91191 Gif-sur-Yvette, France.
Silicate glasses are commonly used for many important industrial applications. As such, the literature provides a wealth of different structural, physical, thermodynamic and mechanical properties for many different chemical compositions of oxide glasses. However, a frequent limitation to existing datasets is that only one or two material properties can be evaluated for a given sample.
View Article and Find Full Text PDFInsights into Calcium Phosphate Formation Induced by the Dissolution of 45S5 Bioactive Glass.
ACS Biomater Sci Eng
January 2025
CEA, DES, ISEC, DPME, SEME, University of Montpellier, Marcoule, Bagnols-sur-Cèze F-30207, France.
Although models have been proposed to explain the mechanisms of bioglass (BG) dissolution and subsequent calcium phosphate (CaP) mineralization, open questions remain. The processes in which phase transition occurs in aqueous solutions and their dynamics remain underexplored partly because traditional instruments/techniques do not allow for direct observations at the adequate time and length scales at which such phase transformations occur. For instance, given the crucial role of the silica gel in CaP formation during BG dissolution, uncertainty exists about how such a silica gel forms on the BG surface.
View Article and Find Full Text PDFAllostery and Evolution: A Molecular Journey Through the Structural and Dynamical Landscape of an Enzyme Super Family.
Mol Biol Evol
January 2025
Univ. Grenoble Alpes, CNRS, CEA, IBS, 38000 Grenoble, France.
Allosteric regulation is a powerful mechanism for controlling the efficiency of enzymes. Deciphering the evolutionary mechanisms by which allosteric properties have been acquired in enzymes is of fundamental importance. We used the malate (MalDH) and lactate deydrogenases (LDHs) superfamily as model to elucidate this phenomenon.
View Article and Find Full Text PDFTopical Brimonidine Tartrate 0.33% Gel versus 577-nm Pro-yellow Laser for the Treatment of Post-acne Erythema: A Comparative Study.
J Clin Aesthet Dermatol
January 2025
Drs. Obaid and Fouda are with the Department of Dermatology, Venereology, and Andrology, Damietta Faculty of Medicine in Al-Azhar University, Egypt.
Background: Post acne erythema (PAE) is a common sequela of inflammatory acne vulgaris resulting from the dilatation of microcapillaries within the papillary dermis, thinning of the epidermis, and release of inflammatory cytokines. The authors sought to compare the safety and efficacy of topical Brimonidine tartrate 0.33% gel versus A 577-nm pro-yellow laser for treatment of post acne erythema.
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