Visualizing the obscure- Chromophore-assisted retinal break detection.

Indian J Ophthalmol

Vitreoretinal Services, Amita Eye Care, Tiruvalla, Kerala, India.

Published: November 2024

AI Article Synopsis

Article Abstract

Background: Finding a retinal break which is responsible for retinal detachment is a critical step in the surgical treatment of this condition. In spite of improvement in visualization systems in pars plana vitrectomy, identifying the break which is the source of subretinal fluid (SRF) could pose a challenge, especially in complex retinal detachments or re-detachments with extensive laser scars.

Purpose: The current technique of break identification involves direct detection of the break via peripheral indentation or using perfluorocarbon liquid (PFCL) to displace SRF from the posterior retina to the periphery and visualizing the proteinaceous SRF egress from the retinal break. In retinal detachments, if no peripheral breaks are visualized, surgeons tend to make a posterior draining retinotomy and drain SRF, the necessity of which can be confirmed after subretinal brilliant blue green (BBG) dye injection. In addition, in already vitrectomized eyes where it can be difficult to identify SRF egressing via the break, subretinal BBG dye provides a color contrast that enhances break visualization.

Synopsis: A method to identify these occult breaks was required, which is described in this video. Hence, the idea of BBG dye injection into the subretinal space with a 41G subretinal needle was thought of. PFCL would be placed over the posterior pole, which would displace the dye to the periphery, and this would disperse out into the vitreous cavity into a blue plume via the break, thereby leading to its identification.

Highlights: Subretinal dye injection is useful for occult retinal break detection as it provides a color contrast. A posterior draining retinotomy can be avoided. It is also useful in recurrent retinal detachments. We describe the use of BBG, which is the least toxic dye available, and report the use of this technique in Indian eyes.

Video Link: https://youtu.be/JGXQjNV9asw.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668196PMC
http://dx.doi.org/10.4103/IJO.IJO_2911_23DOI Listing

Publication Analysis

Top Keywords

retinal break
16
retinal detachments
12
bbg dye
12
dye injection
12
break
10
retinal
8
break detection
8
posterior draining
8
draining retinotomy
8
color contrast
8

Similar Publications

Genetic medicines, including CRISPR/Cas technologies, extend tremendous promise for addressing unmet medical need in inherited retinal disorders and other indications; however, there remain challenges for the development of therapeutics. Herein, we evaluate genome editing by engineered Cas9 ribonucleoproteins (eRNP) in vivo via subretinal administration using mouse and pig animal models. Subretinal administration of adenine base editor and double strand break-inducing Cas9 nuclease eRNPs mediate genome editing in both species.

View Article and Find Full Text PDF

Purpose: The aim of this study was to propose a simplified segmental scleral buckling (SSSB) technique that does not require break localization for less-experienced vitreoretinal surgeons.

Materials And Methods: This retrospective study compared the clinical results of 46 conventional and 23 SSSB (conventional segmental SB [CSSB] and SSSB, respectively) procedures in a tertiary referral retinal center in Taiwan between 2008 and 2019. In the CSSB group, breaks were localized during surgery.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigated how the COVID-19 pandemic affected patients with rhegmatogenous retinal detachment (RRD) at Farabi Eye Hospital in Iran, comparing patients from before and during the pandemic.
  • A total of 375 patients were analyzed, revealing that those referred during the pandemic had quicker referral and surgical wait times, but no significant changes in clinical characteristics or surgical outcomes.
  • The use of general anesthesia increased during the pandemic period, prompting the need for further research into this trend.
View Article and Find Full Text PDF

An improvement in visual acuity accompanied by the development of RPE tear: a case report.

BMC Ophthalmol

January 2025

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Background: Retinal pigment epithelium (RPE) tear is a well-known complication of RPE detachment and is typically associated with significant visual acuity decline. However, in this case, despite the occurrence of an RPE tear there was an unexpected improvement in visual acuity.

Case Presentation: A 68-year-old male presented with blurred vision in his right eye of a month's duration.

View Article and Find Full Text PDF

Dry eye disease and morphological changes in the anterior chamber in people with cystic fibrosis.

J Cyst Fibros

January 2025

Pulmonology Department, Regional University Hospital of Malaga, Department of Medicine and Dermatology, University of Malaga, Biomedical Research Institute of Malaga (IBIMA) - Bionand Platform, Malaga, Spain. Electronic address:

Background: Cystic fibrosis (CF) is caused by variants in a gene that encodes a protein essential for water and ion transport in the epithelial cells of exocrine organs. Given the possible relationship of this protein and conjunctival and corneal epithelium, the aim of this study was to evaluate ophthalmologic alterations in people with CF.

Methods: Forty-five people with CF underwent pulmonary evaluation including inflammatory score (IS).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!