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http://dx.doi.org/10.4103/IJO.IJO_2444_24 | DOI Listing |
Int J Biol Macromol
January 2025
Centre for the Environment, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India; Chemical Engineering Department, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India. Electronic address:
Globalization resulted in technological advancement, and urban population growth. Consequently, pollution emerged as an imminent risk to the survival of all species on Earth. Consequently, on a worldwide basis, sustainability become a major issue for legislators.
View Article and Find Full Text PDFDiscov Nano
January 2025
Department of Biotechnology, Alagappa University, Karaikudi, 630003, India.
Diabetic wounds with chronic infections present a significant challenge, exacerbated by the growing issue of antimicrobial resistance, which often leads to delayed healing and increased morbidity. This study introduces a novel silver-zinc oxide-eugenol (Ag+ZnO+EU) nanocomposite, specifically designed to enhance antimicrobial activity and promote wound healing. The nanocomposite was thoroughly characterized using advanced analytical techniques, confirming its nanoscale structure, stability and chemical composition.
View Article and Find Full Text PDFFront Microbiol
January 2025
National Institute for Research in Tuberculosis, Indian Council of Medical Research, Chennai, India.
Pyrazinamide (PZA) is a key first-line antituberculosis drug that plays an important role in eradicating persister (TB) bacilli and shortening the duration of tuberculosis treatment. However, PZA-resistance is on the rise, particularly among persons with multidrug-resistant (MDR) tuberculosis. This nationwide study was conducted to explore the prevalence of mutations conferring PZA resistance, catalogue mutation diversity, investigate the associations of PZA resistance with specific lineages, examine co-resistance to 13 first- and second-line drugs, and evaluate the diagnostic accuracy of sequencing A and D genes for predicting PZA resistance.
View Article and Find Full Text PDFCell Biochem Biophys
January 2025
Division of Biomedical and Life Sciences, School of Science, Navrachana University, Vadodara, Gujarat, India.
Cancer Stem Cells (CSCs) play an important role in the development, resistance, and recurrence of many malignancies. These subpopulations of tumor cells have the potential to self-renew, differentiate, and resist conventional therapy, highlighting their importance in cancer etiology. This review explores the regulatory mechanisms of CSCs in breast, cervical, and lung cancers, highlighting their plasticity, self-renewal, and differentiation capabilities.
View Article and Find Full Text PDFJ Biol Methods
October 2024
Indian Council of Medical Research-National Institute of Occupational Health, Ahmedabad, Gujarat 380016, India.
Background: Earlier studies conducted by Indian researchers have demonstrated that the elimination of tuberculosis (TB) requires proactive control of silicosis, given India's significant burden of silicosis and its common comorbidity, pulmonary TB, also known as silicotuberculosis. The TB Control Indian Health Authority saw human immunodeficiency virus infection, diabetes, and malnutrition, among others, as important risk factors for case findings, but overlooked the significance of silicosis. Silicotuberculosis control is often confronted with challenges of detecting microorganisms, uncertain treatment outcomes, a higher likelihood of mono-drug and multi-drug resistance, and increased mortality due to treatment failure.
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