Background: Hirayama disease (HD) is characterized by slow progression of muscle atrophy without sensory disturbance in a single upper extremity in adolescent boys. HD can be treated using both conservative measures and surgery. However, the optimal treatment remains controversial.
Case Presentation: We have encountered an 18-year-old man with HD who presented to us with a 2-year history of progressive muscle atrophy and weakness of the left upper extremity. He underwent posterior cervical fusion surgery in the extended position without decompression. As of 5 years postoperatively, there has been no deterioration of his muscular atrophy and weakness and his condition has mildly improved. He was able to return to daily life and work with no difficulty.
Conclusions: Although cervical fusion surgery has several risks, including adjacent segment disease, posterior spinal fusion surgery without decompression in the short segment can be considered as a surgical option for HD. J. Med. Invest. 71 : 298-302, August, 2024.
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http://dx.doi.org/10.2152/jmi.71.298 | DOI Listing |
J Med Chem
December 2024
Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Rearranged during transfection (RET) kinase is a validated therapeutic target for various cancers characterized by RET alterations. Although two selective RET inhibitors, selpercatinib and pralsetinib, have been approved by the FDA, acquired resistance through solvent-front mutations has been identified rapidly. Developing proteolysis targeting chimera (PROTAC) targeting RET mutations offers a promising strategy to combat drug resistance.
View Article and Find Full Text PDFVestn Oftalmol
December 2024
Novosibirsk State Regional Hospital, Novosibirsk, Russia.
Purpose: This study evaluated the impact of phacoemulsification cataract surgery (PE) on anatomical and functional parameters, as well as the regimen and frequency of anti-VEGF injections in patients with neovascular age-related macular degeneration (nAMD) over a long-term period (up to 3 years).
Material And Methods: The study included 117 patients (117 eyes) diagnosed with nAMD and cataract, graded by LOCS: LOCS I (=56; 47.9%), LOCS II (=57; 48.
BMC Surg
December 2024
Department of Orthopedics & Elderly Spinal Surgery, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University, Beijing, China.
Objective: To specifically evaluate the safety and benefit of different drainage removal criteria (50 ml and 100 ml per 24 h) in patients undergoing short-level lumbar fusion surgery.
Methods: Patients with degenerative lumbar diseases who underwent short level lumbar fusion with instrumentation between January 2021 and January 2023 were retrospectively recruited in the study. Based on the different criteria for drainage removal, the patients were divided into 2 groups (group A and group B).
Int J Spine Surg
December 2024
Spine Team, Division of Orthopedic Surgery and Musculoskeletal Trauma Care, Geneva University Hospitals, Faculty of Medecine, University of Geneva, Geneva, Switzerland
Background: Navigation increases the precision and safety of pedicle screw placement and has been used to place interbody cages for lateral lumbar interbody fusion. Single-position surgery shortens its duration and that of anesthesia. The aim of this study was the feasibility of simultaneous cage and screw placement in a single prone position using intraoperative navigation without the need for additional fluoroscopy and a detailed technical description of this procedure.
View Article and Find Full Text PDFAm J Otolaryngol
December 2024
Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, Tianjin 300192, China; Institute of Otolaryngology of Tianjin, Tianjin, China; Key Laboratory of Auditory Speech and Balance Medicine, Tianjin, China; Key Clinical Discipline of Tianjin (Otolaryngology), Tianjin, China; Otolaryngology Clinical Quality Control Centre, Tianjin, China.
Purpose: To use deep learning technology to design and implement a model that can automatically classify laryngoscope images and assist doctors in diagnosing laryngeal diseases.
Materials And Methods: The experiment was based on 3057 images (normal, glottic cancer, granuloma, Reinke's Edema, vocal cord cyst, leukoplakia, nodules and polyps) from the dataset Laryngoscope8. A classification model based on deep neural networks was developed and tested.
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