AI Article Synopsis

  • * In a study with 55 pregnant smokers, vitamin C improved umbilical blood flow compared to a placebo, bringing levels closer to those of nonsmokers.
  • * RNA-sequencing results indicated that vitamin C altered gene expression related to vascular and cardiac development, hinting at its potential benefits for baby health in situations of prenatal nicotine exposure.

Article Abstract

Maternal smoking during pregnancy (MSDP), driven by nicotine crossing the placenta, causes lifelong decreases in offspring pulmonary function and vitamin C supplementation during pregnancy prevents some of those changes. We have also shown in animal models of prenatal nicotine exposure that vitamin C supplementation during pregnancy improves placental function. In this study we examined whether vitamin C supplementation mitigates the effects of MSDP on placental structure, function, and gene expression in pregnant human smokers. Doppler ultrasound was performed in a subset of 55 pregnant smokers participating in the "Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function" (VCSIP) randomized clinical trial (NCT01723696) and in 33 pregnant nonsmokers. Doppler ultrasound measurements showed decreased umbilical vein Doppler velocity (Vmax) in placebo-treated smokers that was significantly improved in smokers randomized to vitamin C, restoring to levels comparable to nonsmokers. RNA-sequencing demonstrated that vitamin C supplementation to pregnant smokers was associated with changes in mRNA expression in genes highly relevant to vascular and cardiac development, suggesting a potential mechanism for vitamin C supplementation in pregnant smokers to improve some aspects of offspring health.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513119PMC
http://dx.doi.org/10.1038/s41598-024-73005-7DOI Listing

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