At the ASCO 2024 meeting, Anthony P Conley, coauthor on this editorial, presented promising data from the phase 1/2 clinical trial called BETA PRIME (ClinicalTrials.gov NCT04673942) with AdAPT-001 plus a checkpoint inhibitor (CI). All participants gave informed consent to participate in BETA PRIME before taking part. AdAPT-001 is an oncolytic adenovirus that expresses a transforming growth factor beta (TGF-β) trap to neutralize active TGF-β. This editorial proposes that the TGF-β trap of AdAPT-001 reverses the immunosuppressive environment of tumor cells, and thus makes these tumors susceptible to CIs like the anti-PD-1 agent, nivolumab, and potentially other therapies as well.
Ambrosia beetles (Curculionidae: Scolytinae and Platypodinae) are fungus-farming woodborers that can cause damage to the trees they colonize. Some of these beetles target stressed plants that emit ethanol, and management strategies have proposed using ethanol-injected trees as trap trees to monitor or divert dispersing adult females away from valuable crops. In this study, we used container-grown trees from 8 species to compare the effect of ethanol injection versus flooding on ambrosia beetle host selection and colonization success.
The aim of the present study was to explore the role of ovarian cancer G protein-coupled receptor 1 (OGR1) in osteoclast differentiation and activity induced by extracellular acid. The impact of extracellular acidification on osteoclasts was investigated. Briefly, osteoclasts were generated from RAW 264.
Platypuses are a unique freshwater mammal native to eastern Australia. They are semi-aquatic, predominantly nocturnal, and nest in burrows dug into the banks of waterbodies. Quantifying nesting burrow characteristics is challenging due to the species' cryptic nature.
The trypanosomosis remains unresolved due to its impact on various hosts, leading to production losses in Ethiopia. In the Southwest of Oromia, multiple livestock species share grazing land in tsetse-infested areas. Thus, a cross-sectional study was conducted from December 2020 to December 2021 to determine the prevalence and associated risk factors of trypanosomosis in bovines, small ruminants, and equines, as well as the distribution of the vector in the Dabo Hana district of Southwest Oromia, Ethiopia.
Introduction: Neutrophil autophagy and neutrophil extracellular trap (NET) formation are closely related to asthma pathogenesis. Src homology domain 2-containing protein tyrosine phosphatase 2 (SHP2) is an important regulatory factor in airway remodeling in asthma. This study aimed to explore the molecular mechanisms of SHP2 in neutrophils.
