AI Article Synopsis
- Six new compounds called Euphohelinodes D-I (1-6), which are ent-abietane lactones, were discovered from the plant E. helioscopia, known for its anti-inflammatory properties.
- The structures of these compounds were analyzed using advanced techniques like spectroscopic data, X-ray diffraction, and ECD analysis.
- The most effective compound, euphohelinode H (5), reduced nitric oxide production in inflammatory cells and inhibited key enzymes linked to inflammation via the NF-κB signaling pathway, showing potential for treating inflammatory conditions.
Article Abstract
Euphohelinodes D-I (1-6), six previously unreported ent-abietane lactones, along with two known analogues (7 and 8), were isolated from the anti-inflammatory fraction extracted from E. helioscopia by a bioactivity-guided isolation. Their structures were characterized using a combination of spectroscopic data interpretation, single-crystal X-ray diffraction and ECD analysis. The anti-inflammatory activity of these compounds was evaluated by measuring their inhibitory effects on NO production in LPS-stimulated RAW264.7 macrophages. The most active candidate, euphohelinode H (5), had better inhibitory activity against NO production with an IC value of 30.23 ± 2.33 μM. Further study revealed that 5 significantly suppressed the expressions of iNOS and COX-2 through the NF-κB signaling pathway.
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| http://dx.doi.org/10.1016/j.phytochem.2024.114313 | DOI Listing |
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