AI Article Synopsis
- - The study focuses on the G9P[8] rotavirus A genotype, which has been the main type found in Malaysia since the 2000s, and aims to explore its genetic characteristics and evolution.
- - Researchers analyzed the complete genomes of three G9P[8] strains from young children in Sabah, discovering that they show a DS-1-like genotype instead of the typical Wa-like arrangement.
- - Phylogenetic analysis indicated that two strains were genetically similar to G9P[8]-E2 strains from Japan, hinting at a shared ancestry, and the findings are essential for improving rotavirus monitoring and developing vaccines.
Article Abstract
G9P[8] has been the predominant rotavirus A (RVA) genotype in Malaysia since the 2000s. However, the overall genetic makeup and evolution of Malaysian G9P[8] strains are still unknown. Therefore, this study aimed to evaluate and characterize the complete genomes of three G9P[8] RVA strains isolated from diarrheic children under five years old in Sabah. Contrary to the classical Wa-like constellation, these strains contained a DS-1-like genotype. Two strains, namely L202 and L234, were genotype G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E2-H1, while one (KN102) was genotype G9-P[8]-I1-R1-C1-M1-A2-N1-T1-E1-H1. Phylogenetic analysis revealed that the NSP4 genes of L202 and L234 strains were closer to that of G9P[8]-E2 strains from Japan, suggesting they might share a common ancestor. The findings from this study provide new insights into the genetic characteristics of circulating G9P[8] strains in Sabah, which are important for rotavirus surveillance and potential vaccine development in the region.
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| http://dx.doi.org/10.1016/j.meegid.2024.105685 | DOI Listing |
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