AI Article Synopsis
- The study investigates how alcohol intake before and during early pregnancy affects placental development in female mice.
- Mice exposed to 10% ethanol showed a higher fetal/placental weight ratio and thinner placentas, indicating abnormal growth compared to control mice.
- There were significant changes in the structure of the placenta along with increased AQP3 expression, linking alcohol consumption to placental dysfunction during organ development.
Article Abstract
Adequate trophoblast development during placentation involves the AQP3 regulation. The link between potential placental fetal-maternal interface abnormalities and AQP3 expression after perigestational alcohol intake was not explored yet. Female mice were treated (TF) with 10 % ethanol in drinking water before and up to day 10 of gestation, and control females (CF) with ethanol-free water. At gestational day 13, TFs showed increased fetal/placental weight ratio and reduced histological placental thickness compared to CFs. TF-placentas had disorganized fetal face layers, increased junctional zone (JZ), and decreased labyrinth (Lab). Concomitantly, immunoexpression of cleaved caspase-3 significantly increased in TF-JZ and Lab vs controls. Consistent with placental changes, AQP3 expression was higher in junctional trophoblast giant cells (TGCs), glycogen cells (GCs), spongiotrophoblasts (spg), and lab-syncytiotrophoblasts compared to CF-placentas. This study reveals, for the first time, that perigestational alcohol consumption up to organogenesis causes abnormal placental development associated with dysregulation of AQP3 expression.
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| http://dx.doi.org/10.1016/j.bbrc.2024.150875 | DOI Listing |
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