This work describes a self-powered wireless temperature sensor platform that can be used for foot ulceration monitoring for diabetic patients. The proposed self-powered sensor platform consists of a piezoelectric bimorph, a power conditioning circuit, a temperature sensor readout circuit, and a wireless module. The piezoelectric bimorph mounted inside the shoe effectively converts the foot movement into electric energy that can power the entire sensor platform. Furthermore, a sensor platform was designed, considering the energy requirement of 4.826 mJ for transmitting one data packet of 18 bytes. The self-powered sensor platform prototype was evaluated with five test subjects with different weights and foot shapes; the test results show the subjects had to walk an average of 119.6 s to transmit the first data packet and an additional average of 71.2 s to transmit the subsequent data packet. The temperature sensor showed a resolution of 0.1 °C and a sensitivity of 56.7 mV/°C with a power conditioning circuit efficiency of 74.5%.
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http://dx.doi.org/10.3390/s24206567 | DOI Listing |
Anal Chem
January 2025
Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, U.K.
Total free thiols are an important marker of the whole-body redox state, which has been shown to be associated with clinical outcome in health and disease. Recent investigations have suggested that increased insight may be gained by monitoring alterations of redox state in response to exercise and hypoxia and to monitor redox trajectories in disease settings. However, conducting such studies is challenging due to the requirement for repeated venous blood sampling and intensive lab work.
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January 2025
Interdisciplinary Nanoscience Center, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C, Denmark.
High-throughput measurement of cellular traction forces at the nanoscale remains a significant challenge in mechanobiology, limiting our understanding of how cells interact with their microenvironment. Here, we present a novel technique for fabricating protein nanopatterns in standard multiwell microplate formats (96/384-wells), enabling the high-throughput quantification of cellular forces using DNA tension gauge tethers (TGTs) amplified by CRISPR-Cas12a. Our method employs sparse colloidal lithography to create nanopatterned surfaces with feature sizes ranging from sub 100 to 800 nm on transparent, planar, and fully PEGylated substrates.
View Article and Find Full Text PDFDrug discovery continues to face a staggering 90% failure rate, with many setbacks occurring during late-stage clinical trials. To address this challenge, there is an increasing focus on developing and evaluating new technologies to enhance the "design" and "test" phases of antibody-based drugs (e.g.
View Article and Find Full Text PDFChem Sci
January 2025
School of Chemistry and Materials Science, Jiangsu Normal University Xuzhou 221116 China
Reactive oxygen species (ROS) play a critical role in regulating various physiological processes. To gain a comprehensive understanding of their distinct functions in different physiological events, it is imperative to detect binary ROS simultaneously. However, the development of the sensing method capable of binary ROS detection remains a significant challenge.
View Article and Find Full Text PDFHardwareX
March 2025
Instituto de Investigacion Astronomico y Aeroespacial Pedro Paulet, Universidad Nacional de San Agustin de Arequipa, 04000, Arequipa, Peru.
Inertial navigation systems (INS) are widely used in commercial aviation, maritime navigation, and unmanned vehicle guidance. However, these systems are often sensitive, costly, and challenging to access. To address these limitations, an open-source, low-cost platform named INS OpenNavSense has been developed.
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