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Platelet-Derived Growth Factor Promotes Glomerular Mesangial Cells Differentiation of Human Bone Marrow Hematopoietic Stem Cells - An In Vitro Study.
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Stem Cell Laboratory, Department of Biotechnology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Glomerular filtration function and homeostasis are largely due to the cross-talk between podocytes, endothelial cells, and mesangial cells (MCs). Any disturbance in this association causes glomerular diseases (GD). Cell-based therapies are the best option in the treatment of GD.
View Article and Find Full Text PDFLILRB3 genetic variation is associated with kidney transplant failure in African American recipients.
Nat Med
March 2025
Renal Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
African American (AA) kidney transplant recipients exhibit a higher rate of graft loss compared with other racial and ethnic populations, highlighting the need to identify causative factors. Here, in the Genomics of Chronic Allograft Rejection cohort, pretransplant blood RNA sequencing revealed a cluster of four consecutive missense single-nucelotide polymorphisms (SNPs), within the leukocyte immunoglobulin-like receptor B3 (LILRB3) gene, strongly associated with death-censored graft loss. This SNP cluster (named LILRB3-4SNPs) encodes missense mutations at amino acids 617-618 proximal to a SHP1/2 phosphatase-binding immunoreceptor tyrosine-based inhibitory motif.
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Department of Cardiovascular Medicine, Center for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluation, Shanghai Key Lab of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Time in target range (TTR) of systolic blood pressure is a novel measure to assess the effect of blood pressure control. However, few studies have explored the renoprotective value of systolic TTR in patients with type 2 diabetes (T2D). We analyzed the database of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) blood pressure (BP) trial.
View Article and Find Full Text PDFTissue factor pathway inhibitor levels and atherothrombotic events in patients with chronic kidney disease or diabetes.
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Northern Clinical Diagnostics and Thrombovascular Research (NECTAR), Northern Health, Melbourne, Australia.
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View Article and Find Full Text PDFSerum IL-6 and IL-10 levels are associated with fatal outcomes in patients with SFTS in China.
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Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230001, China.
Introduction: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high mortality rate and is a public health concern. This study aimed to investigate the associations of serum interleukin 6 (IL-6) and interleukin 10 (IL-10) levels with the prognosis of SFTS patients.
Methodology: A total of 95 patients with confirmed SFTS were included.
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