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Hunting the Cell Cycle . | LitMetric

Hunting the Cell Cycle .

Life (Basel)

Laboratory of Bacterial Communication and Anti-Infection Strategies, EA 4312, University of Rouen, 76000 Rouen, France.

Published: September 2024

AI Article Synopsis

  • The author examines the bacterial cell cycle, updating mechanisms that regulate it, including factors like calcium dynamics and membrane structures, informed by physical and chemical principles.
  • Key questions explored include the reasons behind DNA replication processes, the structure of DNA, and the concepts of cell division and metabolic balance.
  • The text also suggests new experimental methods for testing theories related to the bacterial cell cycle, along with innovative ideas about DNA packing and virtual bacterial computation.

Article Abstract

In this very personal hunt for the meaning of the bacterial cell cycle, the , I briefly revisit and update some of the mechanisms we and many others have proposed to regulate the bacterial cell cycle. These mechanisms, which include the dynamics of calcium, membranes, hyperstructures, and networks, are based on physical and physico-chemical concepts such as ion condensation, phase transition, crowding, liquid crystal immiscibility, collective vibrational modes, reptation, and water availability. I draw on ideas from subjects such as the 'prebiotic ecology' and phenotypic diversity to help with the hunt. Given the fundamental nature of the , I would expect that its capture would make sense of other parts of biology. The route, therefore, followed by the hunt has involved trying to answer questions like "why do cells replicate their DNA?", "why is DNA replication semi-conservative?", "why is DNA a double helix?", "why do cells divide?", "is cell division a spandrel?", and "how are catabolism and anabolism balanced?". Here, I propose some relatively unexplored, experimental approaches to testing -related hypotheses and, finally, I propose some possibly original ideas about DNA packing, about phase separations, and about computing with populations of virtual bacteria.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509034PMC
http://dx.doi.org/10.3390/life14101213DOI Listing

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