AI Article Synopsis
- Twelve new isoindolin-1-one compounds, named erinacenones A-L, were discovered from the medicinal fungus through liquid cultures.
- Their structures were determined using various spectroscopic techniques, and the absolute configuration was figured out by comparing optical rotations to literature values.
- Notably, two pairs of these compounds are isomers differing by one double bond, and two of the compounds showed cytotoxic effects against MCF-7 cancer cell lines with IC values of 24.7 and 18.4 μM.
Article Abstract
A total of twelve previously unreported isoindolin-1-one compounds, erinacenones A-L (-), were isolated from liquid cultures of the medicinal fungus . Their structures were elucidated based on spectroscopic data analysis. The absolute configuration of was determined by comparing its optical rotations with values reported in the literature. The most distinctive feature of these compounds is that their nitrogen atoms are connected to different parts of the special structure moieties. Among them, compounds and , as well as and , are two pairs of isomers differing only by a small change in the position of one double bond. Compounds and were found to show cytotoxic activities, with IC values of 24.7 and 18.4 μM, respectively, against MCF-7 cell lines.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510660 | PMC |
| http://dx.doi.org/10.3390/molecules29204901 | DOI Listing |
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