AI Article Synopsis
- N-methyl-D-aspartate receptors (NMDARs) are crucial for many neurological functions, and their dysfunction is linked to various mental health disorders.
- The review thoroughly examines NMDARs, covering their molecular structure, how they are activated, and their roles in brain physiology, as well as their contribution to conditions like stroke, epilepsy, and schizophrenia.
- The paper evaluates the effectiveness and drawbacks of different NMDAR antagonists used for diagnosis and treatment.
Article Abstract
Background: N-methyl-D-aspartate receptors (NMDARs) are members of the ionotropic glutamate receptor family. These ligand-gated channels are entwined with numerous fundamental neurological functions within the central nervous system (CNS), and numerous neuropsychiatric disorders may arise from their malfunction.
Methods: The purpose of the present review is to provide a detailed description of NMDARs by addressing their molecular structures, activation mechanisms, and physiological roles in the mammalian brain. In the second part, their role in various neuropsychiatric disorders including stroke, epilepsy, anti-NMDA encephalitis, Alzheimer's and Huntington's diseases, schizophrenia, depression, neuropathic pain, opioid-induced tolerance, and hyperalgesia will be covered.
Results: Finally, through a careful exploration of the main non-competitive NMDARs antagonists (channel-blockers).
Conclusion: We discuss the strengths and limitations of the various molecular structures developed for diagnostic or therapeutic purposes.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509972 | PMC |
| http://dx.doi.org/10.3390/ph17101265 | DOI Listing |
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